Synthesis in E. coli of a polypeptide with human leukocyte interferon activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-03

AUTHORS

Shigekazu Nagata, Hideharu Taira, Alan Hall, Lorraine Johnsrud, Michel Streuli, Josef Ecsödi, Werner Boll, Kari Cantell, Charles Weissmann

ABSTRACT

Double-stranded cDNA prepared from the 12S fraction of poly (A) RNA from interferon (IF)-producing human leukocytes was cloned in Escherichia coli using the pBR322 vector. One of the resulting clones had a 910-base pair insert which could hybridise to IF mRNA and was responsible for the production of a polypeptide with biological IF activity. Up to 10,000 units IF activity per g of cells was obtained from some clones. More... »

PAGES

316-320

Journal

TITLE

Nature

ISSUE

5754

VOLUME

284

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/284316a0

    DOI

    http://dx.doi.org/10.1038/284316a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020682127

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6987533


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