Genetic variance of laboratory outbred Swiss mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-01

AUTHORS

M. Catherine Rice, Stephen J. O'Brien

ABSTRACT

The extent of allelic variation has been estimated at 46 structural gene loci within three major colonies of Swiss mice and between inbred derivative strains. The colonies have retained nearly the same amount and type of variation found in natural murine or human populations despite laboratory propagation for more than 50 years (175 generations). The population genetic structures of the Swiss mouse colonies were comparable to an island population in which random fixation, and not inbreeding or population bottlenecks, is apparently responsible for slight losses in genetic variance. More... »

PAGES

157-161

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/283157a0

DOI

http://dx.doi.org/10.1038/283157a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005114636

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7350540


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