Regulation of lymphocyte mitogenesis by (2′–5′) oligo-isoadenylate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-12

AUTHORS

Adi Kimchi, Helen Shure, Michel Revel

ABSTRACT

Interferon has been reported to affect cell proliferation in various tumour and normal cell cultures1. In human cells, the anti-growth effect of Interferon is under the control of chromosome 21, like the antiviral effect2,3, and the two activities appear to reside in the same glycoprotein4. In synchronised fibroblast cultures Interferon inhibited DNA synthesis by blocking initiations of DNA replication5,6. Another system in which the inhibitory effect of interferon on DNA synthesis was particularly clear is lymphocyte mitogenesis. In lymphocytes stimulated by lectin mitogens or allogeneic cells, interferon inhibits DNA synthesis, and the RNA and protein synthesis observed before the S phase of the cell cycle7–9. In interferon-treated ceUs, several enzymes are induced, including the (2′–5′) oligo-isoadenylate [oligo(A)] synthetase E, which polymerises ATP into a series of oligonucleotides of general structure ppp(A2′p)n5′A (refs 10–12). The (2′–5′) oligonucleotides inhibit protein synthesis when added to cell-free systems10–12 or hypotonically permeabilised cells13, and the induction of (2′–5′) oligo(A) synthetase was correlated with the antiviral action of interferon14,15. In the present work, the involvement of this enzyme in the antigrowth effect of interferon was studied. We show that addition of the (2′–5′) oligo(A)nucleotides to the culture medium of intact lymphocytes mimics the antimitogenic effect of interferon. Experiments with lymphocyte extracts show that, while interferon increases the (2′–5′)oligo(A) synthetase E, the mitogenic stimulus of concanavalin A leads to a decrease in (2′–5′) oligo(A) accumulation. More... »

PAGES

849-851

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/282849a0

DOI

http://dx.doi.org/10.1038/282849a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042017562

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/514363


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