T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-10

AUTHORS

Leroy F. Liu, Chung-Cheng Liu, Bruce M. Alberts

ABSTRACT

A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

PAGES

456-461

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/281456a0

DOI

http://dx.doi.org/10.1038/281456a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015641106

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/226889


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