Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-10

AUTHORS

M. Roussel, S. Saule, C. Lagrou, C. Rommens, H. Beug, T. Graf, D. Stehelin

ABSTRACT

The RNAs of seven replication-defective leukaemia virus (DLV) strains contain three types of unique sequences, which correlate with the capacity of a given virus strain to transform erythroblasts, macrophage-like cells and myeloblasts, respectively. These sequences, termed erb, mac and myb, have their counterparts in the normal DNA of avian and mammalian species. Our results indicate that DLVs represent recombinants between a common ‘vector’ related to a chicken endogenous virus and one of three types of cellular gene possibly involved in haematopoietic differentiation. More... »

PAGES

452-455

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/281452a0

DOI

http://dx.doi.org/10.1038/281452a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027487244

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/226888


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