A structurally abnormal insulin causing human diabetes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-09

AUTHORS

H Tager, B Given, D Baldwin, M Mako, J Markese, A Rubenstein, J Olefsky, M Kobayashi, O Kolterman, R Poucher

ABSTRACT

Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalanine substitution at position 24 or 25 of the insulin B-chain. More... »

PAGES

122-125

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/281122a0

DOI

http://dx.doi.org/10.1038/281122a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046468684

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/381941


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