Three-dimensional structure of the Stat3β homodimer bound to DNA View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-07

AUTHORS

Stefan Becker, Bernd Groner, Christoph W. Müller

ABSTRACT

STAT proteins are a family of eukaryotic transcription factors that mediate the response to a large number of cytokines and growth factors. Upon activation by cell-surface receptors or their associated kinases, STAT proteins dimerize, translocate to the nucleus and bind to specific promoter sequences on their target genes. Here we report the first crystal structure of a STAT protein bound to its DNA recognition site at 2.25 A resolution. The structure provides insight into the various steps by which STAT proteins deliver a response signal directly from the cell membrane to their target genes in the nucleus. More... »

PAGES

145-151

Journal

TITLE

Nature

ISSUE

6689

VOLUME

394

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/28101

DOI

http://dx.doi.org/10.1038/28101

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018049595

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9671298


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