Evidence that murine pre-B cells synthesise μ heavy chains but no light chains View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-08

AUTHORS

JOHN F. KEAEY, MARK LEJEUNE, PETER BURROWS

ABSTRACT

THE first identifiable member of the B-cell line, termed the pre-B-cell, has been shown by immunofluorescent techniques to contain small amounts of intracellular IgM, but to lack detectable surface immunoglobulin1. These cells have been found in several species at sites of B-cell generation, most notably fetal liver and adult bone marrow1,2 and considerable evidence now exists which supports this precursor–progeny relationship of pre-B cells and B lymphocytes1–5. However, conflicting data exist with regard to pre-B cell expression of μ and light chains. Although these cells were originally described in mice as containing both intracellular heavy (μ) and light chains1, using the same immunofluorescence techniques we have subsequently been unable to demonstrate either κ or λ light chains within these cells (P.B. and J.K., unpublished). Moreover, the presence of light chains in murine pre-B cells cannot be confirmed with the original anti-κ antibodies used in ref. 1 (M. Cooper, personal communication). These findings are also contrary to immuno-chemical data which suggest the presence of complete IgM molecules both intracellularly and on the surface of early fetal liver cells6. We have used somatic cell hybridisation to approach this controversial issue. We have now obtained, after fusion with fetal liver, hybridomas which synthesise large amounts of intracellular μ chain in the absence of any light chain (LC) synthesis detectable by immunofluorescent or immunochemical techniques. The immunoglobulin phenotype of these hybridomas is identical to that observed in immunofluorescence studies of pre-B cells from fetal liver or adult bone marrow, and suggests that synthesis of μ chain before light chain expression is a normal event in the early differentiation of the B-cell line. More... »

PAGES

838

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/280838a0

DOI

http://dx.doi.org/10.1038/280838a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038928567

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/112480


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hybrid Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Heavy Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Light Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin mu-Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myeloma Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "KEAEY", 
        "givenName": "JOHN F.", 
        "type": "Person"
      }, 
      {
        "familyName": "LEJEUNE", 
        "givenName": "MARK", 
        "type": "Person"
      }, 
      {
        "familyName": "BURROWS", 
        "givenName": "PETER", 
        "id": "sg:person.01351177660.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351177660.16"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/256495a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001387921", 
          "https://doi.org/10.1038/256495a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830071112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002187442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0008-8749(74)90233-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011414379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/249361a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020642220", 
          "https://doi.org/10.1038/249361a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1977.tb00382.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027700902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(79)90014-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038826140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/259224a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045841484", 
          "https://doi.org/10.1038/259224a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/259224a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045841484", 
          "https://doi.org/10.1038/259224a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/271249a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046569942", 
          "https://doi.org/10.1038/271249a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/271249a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046569942", 
          "https://doi.org/10.1038/271249a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1974.tb03599.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052877810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/sqb.1977.041.01.089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060404680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.145.3633.709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062483252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074694709", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074710674", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079506272", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079545532", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080103299", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083274714", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1979-08", 
    "datePublishedReg": "1979-08-01", 
    "description": "THE first identifiable member of the B-cell line, termed the pre-B-cell, has been shown by immunofluorescent techniques to contain small amounts of intracellular IgM, but to lack detectable surface immunoglobulin1. These cells have been found in several species at sites of B-cell generation, most notably fetal liver and adult bone marrow1,2 and considerable evidence now exists which supports this precursor\u2013progeny relationship of pre-B cells and B lymphocytes1\u20135. However, conflicting data exist with regard to pre-B cell expression of \u03bc and light chains. Although these cells were originally described in mice as containing both intracellular heavy (\u03bc) and light chains1, using the same immunofluorescence techniques we have subsequently been unable to demonstrate either \u03ba or \u03bb light chains within these cells (P.B. and J.K., unpublished). Moreover, the presence of light chains in murine pre-B cells cannot be confirmed with the original anti-\u03ba antibodies used in ref. 1 (M. Cooper, personal communication). These findings are also contrary to immuno-chemical data which suggest the presence of complete IgM molecules both intracellularly and on the surface of early fetal liver cells6. We have used somatic cell hybridisation to approach this controversial issue. We have now obtained, after fusion with fetal liver, hybridomas which synthesise large amounts of intracellular \u03bc chain in the absence of any light chain (LC) synthesis detectable by immunofluorescent or immunochemical techniques. The immunoglobulin phenotype of these hybridomas is identical to that observed in immunofluorescence studies of pre-B cells from fetal liver or adult bone marrow, and suggests that synthesis of \u03bc chain before light chain expression is a normal event in the early differentiation of the B-cell line.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/280838a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2449470", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5725", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "280"
      }
    ], 
    "name": "Evidence that murine pre-B cells synthesise \u03bc heavy chains but no light chains", 
    "pagination": "838", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b96f6b758045ec24d2dbaeea7b01b8fb3e90d61061462e3eb475c25e8ac9e63c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "112480"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/280838a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038928567"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/280838a0", 
      "https://app.dimensions.ai/details/publication/pub.1038928567"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/280838a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/280838a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/280838a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/280838a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/280838a0'


 

This table displays all metadata directly associated to this object as RDF triples.

166 TRIPLES      21 PREDICATES      56 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/280838a0 schema:about N3154bf791d29487b8c826aa14fa117e0
2 N39b833e6c14e42bdb5a384c21e84e220
3 N3ca05d52ccce46e0a56d5f14c257794e
4 N456dca27dbf2451ab41ae59ea0b2c816
5 N50da9f05135d46e68d21f64d6f6b8307
6 N67b5d432ca6440d1a1bb41aa413df338
7 N6a1d0a80f6fe4afa8ec3d4878f91c831
8 Ndda5de4b089441c3bd3042b23b5ac4e2
9 Neb2a7d4bc769471c9fb15d2580dd0b5e
10 Nfbcff1f50e744e1b88c44a5f5479091f
11 anzsrc-for:11
12 anzsrc-for:1114
13 schema:author N41deee5b7b5340b59caa2c449fb775d5
14 schema:citation sg:pub.10.1038/249361a0
15 sg:pub.10.1038/256495a0
16 sg:pub.10.1038/259224a0
17 sg:pub.10.1038/271249a0
18 https://app.dimensions.ai/details/publication/pub.1074694709
19 https://app.dimensions.ai/details/publication/pub.1074710674
20 https://app.dimensions.ai/details/publication/pub.1079506272
21 https://app.dimensions.ai/details/publication/pub.1079545532
22 https://app.dimensions.ai/details/publication/pub.1080103299
23 https://app.dimensions.ai/details/publication/pub.1083274714
24 https://doi.org/10.1002/eji.1830071112
25 https://doi.org/10.1016/0008-8749(74)90233-0
26 https://doi.org/10.1016/0092-8674(79)90014-x
27 https://doi.org/10.1101/sqb.1977.041.01.089
28 https://doi.org/10.1111/j.1432-1033.1974.tb03599.x
29 https://doi.org/10.1111/j.1600-065x.1977.tb00382.x
30 https://doi.org/10.1126/science.145.3633.709
31 schema:datePublished 1979-08
32 schema:datePublishedReg 1979-08-01
33 schema:description THE first identifiable member of the B-cell line, termed the pre-B-cell, has been shown by immunofluorescent techniques to contain small amounts of intracellular IgM, but to lack detectable surface immunoglobulin1. These cells have been found in several species at sites of B-cell generation, most notably fetal liver and adult bone marrow1,2 and considerable evidence now exists which supports this precursor–progeny relationship of pre-B cells and B lymphocytes1–5. However, conflicting data exist with regard to pre-B cell expression of μ and light chains. Although these cells were originally described in mice as containing both intracellular heavy (μ) and light chains1, using the same immunofluorescence techniques we have subsequently been unable to demonstrate either κ or λ light chains within these cells (P.B. and J.K., unpublished). Moreover, the presence of light chains in murine pre-B cells cannot be confirmed with the original anti-κ antibodies used in ref. 1 (M. Cooper, personal communication). These findings are also contrary to immuno-chemical data which suggest the presence of complete IgM molecules both intracellularly and on the surface of early fetal liver cells6. We have used somatic cell hybridisation to approach this controversial issue. We have now obtained, after fusion with fetal liver, hybridomas which synthesise large amounts of intracellular μ chain in the absence of any light chain (LC) synthesis detectable by immunofluorescent or immunochemical techniques. The immunoglobulin phenotype of these hybridomas is identical to that observed in immunofluorescence studies of pre-B cells from fetal liver or adult bone marrow, and suggests that synthesis of μ chain before light chain expression is a normal event in the early differentiation of the B-cell line.
34 schema:genre research_article
35 schema:inLanguage en
36 schema:isAccessibleForFree false
37 schema:isPartOf N304444746c924a56b9c1c71d652f42ab
38 Nb6ea5ebfdb6345638301bb577fd83b66
39 sg:journal.1018957
40 schema:name Evidence that murine pre-B cells synthesise μ heavy chains but no light chains
41 schema:pagination 838
42 schema:productId N6e07b1ae77ac455e93ef6a25576d1270
43 N89fff96fd42647389f4613f57076cd64
44 Na7027c03ac674ef3b90c72ea2ed3b06e
45 Nef352ddcba6d409ba474236ac42f6592
46 Nf9ce7c243011413d87be8f270685a6ae
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038928567
48 https://doi.org/10.1038/280838a0
49 schema:sdDatePublished 2019-04-10T13:56
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher N5df86b61cf6d4e1a86114af8a3bb2c0d
52 schema:url https://www.nature.com/articles/280838a0
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N0e66d6f34cd94dcd8b72d4bff0ee4406 rdf:first N8f0172cda7a947f497d451e0f4e22046
57 rdf:rest Nf670e8fc6d074ebdbce31264065e6afc
58 N304444746c924a56b9c1c71d652f42ab schema:volumeNumber 280
59 rdf:type schema:PublicationVolume
60 N3154bf791d29487b8c826aa14fa117e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Immunoglobulin Heavy Chains
62 rdf:type schema:DefinedTerm
63 N39b833e6c14e42bdb5a384c21e84e220 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Liver
65 rdf:type schema:DefinedTerm
66 N3ca05d52ccce46e0a56d5f14c257794e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Mice
68 rdf:type schema:DefinedTerm
69 N41deee5b7b5340b59caa2c449fb775d5 rdf:first N9dc16d1c8b4f4886adb652d78fb5cdb5
70 rdf:rest N0e66d6f34cd94dcd8b72d4bff0ee4406
71 N456dca27dbf2451ab41ae59ea0b2c816 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Cell Differentiation
73 rdf:type schema:DefinedTerm
74 N50da9f05135d46e68d21f64d6f6b8307 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Immunoglobulin Light Chains
76 rdf:type schema:DefinedTerm
77 N5df86b61cf6d4e1a86114af8a3bb2c0d schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N67b5d432ca6440d1a1bb41aa413df338 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Hybrid Cells
81 rdf:type schema:DefinedTerm
82 N6a1d0a80f6fe4afa8ec3d4878f91c831 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name B-Lymphocytes
84 rdf:type schema:DefinedTerm
85 N6e07b1ae77ac455e93ef6a25576d1270 schema:name readcube_id
86 schema:value b96f6b758045ec24d2dbaeea7b01b8fb3e90d61061462e3eb475c25e8ac9e63c
87 rdf:type schema:PropertyValue
88 N89fff96fd42647389f4613f57076cd64 schema:name pubmed_id
89 schema:value 112480
90 rdf:type schema:PropertyValue
91 N8f0172cda7a947f497d451e0f4e22046 schema:familyName LEJEUNE
92 schema:givenName MARK
93 rdf:type schema:Person
94 N9dc16d1c8b4f4886adb652d78fb5cdb5 schema:familyName KEAEY
95 schema:givenName JOHN F.
96 rdf:type schema:Person
97 Na7027c03ac674ef3b90c72ea2ed3b06e schema:name dimensions_id
98 schema:value pub.1038928567
99 rdf:type schema:PropertyValue
100 Nb6ea5ebfdb6345638301bb577fd83b66 schema:issueNumber 5725
101 rdf:type schema:PublicationIssue
102 Ndda5de4b089441c3bd3042b23b5ac4e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Animals
104 rdf:type schema:DefinedTerm
105 Neb2a7d4bc769471c9fb15d2580dd0b5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Myeloma Proteins
107 rdf:type schema:DefinedTerm
108 Nef352ddcba6d409ba474236ac42f6592 schema:name nlm_unique_id
109 schema:value 0410462
110 rdf:type schema:PropertyValue
111 Nf670e8fc6d074ebdbce31264065e6afc rdf:first sg:person.01351177660.16
112 rdf:rest rdf:nil
113 Nf9ce7c243011413d87be8f270685a6ae schema:name doi
114 schema:value 10.1038/280838a0
115 rdf:type schema:PropertyValue
116 Nfbcff1f50e744e1b88c44a5f5479091f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Immunoglobulin mu-Chains
118 rdf:type schema:DefinedTerm
119 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
120 schema:name Medical and Health Sciences
121 rdf:type schema:DefinedTerm
122 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
123 schema:name Paediatrics and Reproductive Medicine
124 rdf:type schema:DefinedTerm
125 sg:grant.2449470 http://pending.schema.org/fundedItem sg:pub.10.1038/280838a0
126 rdf:type schema:MonetaryGrant
127 sg:journal.1018957 schema:issn 0090-0028
128 1476-4687
129 schema:name Nature
130 rdf:type schema:Periodical
131 sg:person.01351177660.16 schema:familyName BURROWS
132 schema:givenName PETER
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351177660.16
134 rdf:type schema:Person
135 sg:pub.10.1038/249361a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020642220
136 https://doi.org/10.1038/249361a0
137 rdf:type schema:CreativeWork
138 sg:pub.10.1038/256495a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001387921
139 https://doi.org/10.1038/256495a0
140 rdf:type schema:CreativeWork
141 sg:pub.10.1038/259224a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045841484
142 https://doi.org/10.1038/259224a0
143 rdf:type schema:CreativeWork
144 sg:pub.10.1038/271249a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046569942
145 https://doi.org/10.1038/271249a0
146 rdf:type schema:CreativeWork
147 https://app.dimensions.ai/details/publication/pub.1074694709 schema:CreativeWork
148 https://app.dimensions.ai/details/publication/pub.1074710674 schema:CreativeWork
149 https://app.dimensions.ai/details/publication/pub.1079506272 schema:CreativeWork
150 https://app.dimensions.ai/details/publication/pub.1079545532 schema:CreativeWork
151 https://app.dimensions.ai/details/publication/pub.1080103299 schema:CreativeWork
152 https://app.dimensions.ai/details/publication/pub.1083274714 schema:CreativeWork
153 https://doi.org/10.1002/eji.1830071112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002187442
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/0008-8749(74)90233-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011414379
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/0092-8674(79)90014-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038826140
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1101/sqb.1977.041.01.089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060404680
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1111/j.1432-1033.1974.tb03599.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052877810
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1111/j.1600-065x.1977.tb00382.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027700902
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1126/science.145.3633.709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062483252
166 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...