Involvement of a gene on chromosome 9 in human fibroblast Interferon production View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-08

AUTHORS

A. MEAGER, H. GRAVES, D. C. BURKE, D. M. SWALLOW

ABSTRACT

HUMAN fibroblast interferon is a single monomeric gly-coprotein1, and presumably a single structural gene codes for the human interferon polypeptide. It was originally reported that chromosomes 2 and 5 were necessary together for human interferon production2. More recent evidence suggests that both chromosomes 2 and 5 carry separate human interferon genes3,4. However, we have found, in two separate series of human–mouse somatic cell hybrid cell lines and their diphtheria toxin-resistant subclones5,6, that human interferon production segregated from chromosome 5 and, furthermore, did not correlate with the presence of chromosomes 2 and 5 together7. Furthermore, using 29 hybrid clones (13 independent primary hybrids and 16 subclones) we could exclude chromosomes 1–8, 10–22 and X as candidates for the localisation of a single gene coding for human interferon on the basis of discordance of more than three clones for the segregation of human interferon production and the presence of a particular chromosome. However, there was a good correlation between the production of human interferon and the presence of chromosome 9. Here we demonstrate this directly. More... »

PAGES

493-495

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/280493a0

DOI

http://dx.doi.org/10.1038/280493a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049188606

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/460428


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