A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-08

AUTHORS

J. G. Seidman, Edward E. Max, Philip Leder

ABSTRACT

The active gene for a κ light chain is formed by a somatic recombination event that joins one of several hundred variable region genes to one of a series of recombination sites (J-segments) encoded close to the κ constant region gene. The nucleotide sequences of cloned germ line and somatically recombined genes define the precise organisation of these genetic segments and the site and nature of the recombination event that joined them. Apart from somatic recombination, no further alteration of the germ line sequence has occurred. The J-segment is of special interest as it encodes signals for both DNA and RNA splicing and provides a means of generating further immunoglobulin gene diversity. More... »

PAGES

370-375

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/280370a0

DOI

http://dx.doi.org/10.1038/280370a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029122088

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/111146


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Constant Regions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Light Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Variable Region", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin kappa-Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombination, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Lab. of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, Maryland", 
          "id": "http://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Lab. of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seidman", 
        "givenName": "J. G.", 
        "id": "sg:person.014062720317.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014062720317.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lab. of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, Maryland", 
          "id": "http://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Lab. of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Max", 
        "givenName": "Edward E.", 
        "id": "sg:person.01352240437.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352240437.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lab. of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, Maryland", 
          "id": "http://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Lab. of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leder", 
        "givenName": "Philip", 
        "id": "sg:person.01160603253.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160603253.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/275510a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007205053", 
          "https://doi.org/10.1038/275510a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/276790a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033395984", 
          "https://doi.org/10.1038/276790a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/276785a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016853629", 
          "https://doi.org/10.1038/276785a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/275291a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012827819", 
          "https://doi.org/10.1038/275291a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/276780a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032584407", 
          "https://doi.org/10.1038/276780a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1979-08", 
    "datePublishedReg": "1979-08-01", 
    "description": "The active gene for a \u03ba light chain is formed by a somatic recombination event that joins one of several hundred variable region genes to one of a series of recombination sites (J-segments) encoded close to the \u03ba constant region gene. The nucleotide sequences of cloned germ line and somatically recombined genes define the precise organisation of these genetic segments and the site and nature of the recombination event that joined them. Apart from somatic recombination, no further alteration of the germ line sequence has occurred. The J-segment is of special interest as it encodes signals for both DNA and RNA splicing and provides a means of generating further immunoglobulin gene diversity.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/280370a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5721", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "280"
      }
    ], 
    "keywords": [
      "recombination events", 
      "immunoglobulin gene diversity", 
      "site-specific recombination", 
      "somatic recombination events", 
      "region genes", 
      "constant region genes", 
      "gene diversity", 
      "active genes", 
      "RNA splicing", 
      "germ line", 
      "nucleotide sequence", 
      "somatic recombination", 
      "genetic segments", 
      "genes", 
      "variable region genes", 
      "immunoglobulin genes", 
      "recombination sites", 
      "somatic mutations", 
      "germ-line sequences", 
      "precise organization", 
      "line sequence", 
      "light chain", 
      "recombination", 
      "sequence", 
      "further somatic mutations", 
      "splicing", 
      "further alterations", 
      "DNA", 
      "diversity", 
      "mutations", 
      "sites", 
      "alterations", 
      "segments", 
      "events", 
      "lines", 
      "special interest", 
      "chain", 
      "signals", 
      "organization", 
      "nature", 
      "interest", 
      "series", 
      "means", 
      "further immunoglobulin gene diversity"
    ], 
    "name": "A \u03ba-immunoglobulin gene is formed by site-specific recombination without further somatic mutation", 
    "pagination": "370-375", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029122088"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/280370a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "111146"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/280370a0", 
      "https://app.dimensions.ai/details/publication/pub.1029122088"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_151.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/280370a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/280370a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/280370a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/280370a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/280370a0'


 

This table displays all metadata directly associated to this object as RDF triples.

184 TRIPLES      22 PREDICATES      87 URIs      74 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/280370a0 schema:about N023328a037364ded8ca53498b4a038f6
2 N0952d349d04b4714968c8a8f06cb3cc7
3 N10b8d6b4d44f47a4810434756b988b3a
4 N17c4435211fd42728fb27cea3ae2dba7
5 N1a3443afe7414fc8b8860afb17518da3
6 N29b5c7618150493b996e95bc4c822575
7 N685931cd9cb649b2b76ad65989f232aa
8 Ncd0386c511644160a4ad3b2038c0fafd
9 Nda70fb0ffebd47c7b271a7cb4ff975e9
10 Ne44b5e2eba6c4de88375af0c3230eeef
11 Ne8b759e3a9c0407c959f7bcd492063e9
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author Ne6f0a52f258944318f2f69f98bce5250
15 schema:citation sg:pub.10.1038/275291a0
16 sg:pub.10.1038/275510a0
17 sg:pub.10.1038/276780a0
18 sg:pub.10.1038/276785a0
19 sg:pub.10.1038/276790a0
20 schema:datePublished 1979-08
21 schema:datePublishedReg 1979-08-01
22 schema:description The active gene for a κ light chain is formed by a somatic recombination event that joins one of several hundred variable region genes to one of a series of recombination sites (J-segments) encoded close to the κ constant region gene. The nucleotide sequences of cloned germ line and somatically recombined genes define the precise organisation of these genetic segments and the site and nature of the recombination event that joined them. Apart from somatic recombination, no further alteration of the germ line sequence has occurred. The J-segment is of special interest as it encodes signals for both DNA and RNA splicing and provides a means of generating further immunoglobulin gene diversity.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf N94eecc6790eb423f9976388921e0d6ca
27 Na98cd757de7c48329d3bd0bea489dcf4
28 sg:journal.1018957
29 schema:keywords DNA
30 RNA splicing
31 active genes
32 alterations
33 chain
34 constant region genes
35 diversity
36 events
37 further alterations
38 further immunoglobulin gene diversity
39 further somatic mutations
40 gene diversity
41 genes
42 genetic segments
43 germ line
44 germ-line sequences
45 immunoglobulin gene diversity
46 immunoglobulin genes
47 interest
48 light chain
49 line sequence
50 lines
51 means
52 mutations
53 nature
54 nucleotide sequence
55 organization
56 precise organization
57 recombination
58 recombination events
59 recombination sites
60 region genes
61 segments
62 sequence
63 series
64 signals
65 site-specific recombination
66 sites
67 somatic mutations
68 somatic recombination
69 somatic recombination events
70 special interest
71 splicing
72 variable region genes
73 schema:name A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation
74 schema:pagination 370-375
75 schema:productId N26ad0e8481d442b59230c1b5bdd0eea8
76 N3d31d2b2c2394cf1ae52c3a9f9b495a7
77 Ncc4b7c7c36b840089909261fa987dbf1
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029122088
79 https://doi.org/10.1038/280370a0
80 schema:sdDatePublished 2022-01-01T18:01
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher Nbc21259a51e446baa5b0121de584c382
83 schema:url https://doi.org/10.1038/280370a0
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N023328a037364ded8ca53498b4a038f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Immunoglobulin kappa-Chains
89 rdf:type schema:DefinedTerm
90 N0952d349d04b4714968c8a8f06cb3cc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Animals
92 rdf:type schema:DefinedTerm
93 N10b8d6b4d44f47a4810434756b988b3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Base Sequence
95 rdf:type schema:DefinedTerm
96 N17c4435211fd42728fb27cea3ae2dba7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Recombination, Genetic
98 rdf:type schema:DefinedTerm
99 N1a3443afe7414fc8b8860afb17518da3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Mutation
101 rdf:type schema:DefinedTerm
102 N26ad0e8481d442b59230c1b5bdd0eea8 schema:name pubmed_id
103 schema:value 111146
104 rdf:type schema:PropertyValue
105 N29930bcdd5aa4ddcab8a3f8a30bb2dfd rdf:first sg:person.01160603253.37
106 rdf:rest rdf:nil
107 N29b5c7618150493b996e95bc4c822575 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Antibody Specificity
109 rdf:type schema:DefinedTerm
110 N3d31d2b2c2394cf1ae52c3a9f9b495a7 schema:name doi
111 schema:value 10.1038/280370a0
112 rdf:type schema:PropertyValue
113 N685931cd9cb649b2b76ad65989f232aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Genes
115 rdf:type schema:DefinedTerm
116 N94eecc6790eb423f9976388921e0d6ca schema:volumeNumber 280
117 rdf:type schema:PublicationVolume
118 Na98cd757de7c48329d3bd0bea489dcf4 schema:issueNumber 5721
119 rdf:type schema:PublicationIssue
120 Nbc21259a51e446baa5b0121de584c382 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 Ncc4b7c7c36b840089909261fa987dbf1 schema:name dimensions_id
123 schema:value pub.1029122088
124 rdf:type schema:PropertyValue
125 Ncd0386c511644160a4ad3b2038c0fafd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Immunoglobulin Constant Regions
127 rdf:type schema:DefinedTerm
128 Nda70fb0ffebd47c7b271a7cb4ff975e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Mice
130 rdf:type schema:DefinedTerm
131 Ne44b5e2eba6c4de88375af0c3230eeef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Immunoglobulin Light Chains
133 rdf:type schema:DefinedTerm
134 Ne6f0a52f258944318f2f69f98bce5250 rdf:first sg:person.014062720317.64
135 rdf:rest Nf10aa6da84d24e51bca07ba68002cc60
136 Ne8b759e3a9c0407c959f7bcd492063e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Immunoglobulin Variable Region
138 rdf:type schema:DefinedTerm
139 Nf10aa6da84d24e51bca07ba68002cc60 rdf:first sg:person.01352240437.48
140 rdf:rest N29930bcdd5aa4ddcab8a3f8a30bb2dfd
141 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
142 schema:name Biological Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
145 schema:name Genetics
146 rdf:type schema:DefinedTerm
147 sg:journal.1018957 schema:issn 0028-0836
148 1476-4687
149 schema:name Nature
150 schema:publisher Springer Nature
151 rdf:type schema:Periodical
152 sg:person.01160603253.37 schema:affiliation grid-institutes:grid.420089.7
153 schema:familyName Leder
154 schema:givenName Philip
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160603253.37
156 rdf:type schema:Person
157 sg:person.01352240437.48 schema:affiliation grid-institutes:grid.420089.7
158 schema:familyName Max
159 schema:givenName Edward E.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352240437.48
161 rdf:type schema:Person
162 sg:person.014062720317.64 schema:affiliation grid-institutes:grid.420089.7
163 schema:familyName Seidman
164 schema:givenName J. G.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014062720317.64
166 rdf:type schema:Person
167 sg:pub.10.1038/275291a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012827819
168 https://doi.org/10.1038/275291a0
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/275510a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007205053
171 https://doi.org/10.1038/275510a0
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/276780a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032584407
174 https://doi.org/10.1038/276780a0
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/276785a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016853629
177 https://doi.org/10.1038/276785a0
178 rdf:type schema:CreativeWork
179 sg:pub.10.1038/276790a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033395984
180 https://doi.org/10.1038/276790a0
181 rdf:type schema:CreativeWork
182 grid-institutes:grid.420089.7 schema:alternateName Lab. of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, Maryland
183 schema:name Lab. of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, Maryland
184 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...