Ontology type: schema:ScholarlyArticle
1979-03
AUTHORSSANDRA PHILLIPS, RICHARD P. NOVICK
ABSTRACTPREVIOUS studies have defined a specific element in Staphylococcus aureus containing determinants of inducible erythromycin resistance and spectinomycin resistance. This element has many plasmid-like properties1,2 but is not associated with detectable extra-chromosomal DNA2. The resistances are similar in mechanism to those ordinarily associated with plasmids3,4 (J. Davies, personal communication); the element can be transferred by transduction2 or transformation to a rec− recipient with the same efficiency as to a rec+, and the two determinants show essentially 100% linkage in genetic transfer. Consequently, this linkage group has previously been referred to as a ‘pseudoplasmid’ (ref. 2). On the basis of the results presented here, we suggest that this pseudoplasmid is actually the prototype of a new class of transposon, which functions by means of a highly efficient, represser-controlled, site-specific integration–excision mechanism. This transposon, designated Tn554 (EmSp), can be most easily envisaged as a prophage-like element that lacks replicative autonomy and other vegetative phage functions. More... »
PAGES476-478
http://scigraph.springernature.com/pub.10.1038/278476a0
DOIhttp://dx.doi.org/10.1038/278476a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1039782847
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/156306
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