T antigen is bound to a host protein in SY40-transformed cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-03

AUTHORS

D. P. LANE, L. V. CRAWFO

ABSTRACT

THE early region of the small DNA tumour virus, simian virus 40 (SV40), is known to code for at least two polypeptides, the t and T antigens (‘small t’ and ‘large T’). Both these polypeptides are expressed in cells transformed by the virus1–4, and the T antigen has been shown to be essential for both the initiation and maintenance of the transformed state5–9. We therefore need to know how this T protein interacts with components of the host cell in order to understand the mechanism of SV40-induced transformation. We report here that the T antigen in a line of SV40-transformed mouse cells forms an oligomeric complex with a specific cell coded protein. More... »

PAGES

261-263

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/278261a0

DOI

http://dx.doi.org/10.1038/278261a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001770301

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/218111


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