NK cell-sensitive T-cell subpopulation in thymus: inverse correlation to host NK activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-03

AUTHORS

MONA HANSSON, ROLF KIESSLING, BIRGER ANDERSSON, KLAS KÄRRE, JOHN RODER

ABSTRACT

NATURAL KILLER (NK) cells have been shown to have an important role in resistance to some tumours (see ref. 1 for review) and it has been suggested that these NK cells may represent a T cell and macrophage-independent surveillance mechanism2 similar in principle to the theory proposed by Burnet3 and Thomas4. Recent observations have led to the speculation that NK cells may also have a physiological role in vivo as NK cells were closely associated with the rejection of bone marrow grafts5,6. Although the target ‘antigens’ of NK cells have not yet been fully defined7, a wide range of malignant and non-transformed cells, including normal thymocytes17 and bone marrow cells8 are also sensitive to low levels of NK-mediated cytolysis. We provide evidence here to support the view that the NK cells may be involved in the control of normal T-cell subpopulations within the thymus. More... »

PAGES

174-176

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/278174a0

DOI

http://dx.doi.org/10.1038/278174a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025850663

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/105298


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