Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-01

AUTHORS

Richard C. Mulligan, Bruce H. Howard, Paul Berg

ABSTRACT

Rabbit beta-globin complementary DNA (cDNA) has been inserted into SV40 DNA in place of the gene coding for the virus' major capsid protein, VP1. The recombinant genome, SVGT5-RabetaG, multiplies efficiently in CV1 monkey kidney cell cultures and is transcribed to yield cytoplasmic, polyadenylated hybrid mRNAs containing the beta-globin coding sequence. Cells propagating SVGT5-RabetaG produce substantial quantities of rabbit beta-globin polypeptide. More... »

PAGES

108-114

Journal

TITLE

Nature

ISSUE

5692

VOLUME

277

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/277108a0

    DOI

    http://dx.doi.org/10.1038/277108a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031243977

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/215915


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