Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-10

AUTHORS

Jeffrey K. Tong, Christian A. Hassig, Gavin R. Schnitzler, Robert E. Kingston, Stuart L. Schreiber

ABSTRACT

The dynamic assembly and remodelling of eukaryotic chromosomes facilitate fundamental cellular processes such as DNA replication and gene transcription. The repeating unit of eukaryotic chromosomes is the nucleosome core, consisting of DNA wound about a defined octamer of histone proteins1. Two enzymatic processes that regulate transcription by targeting elements of the nucleosome include ATP-dependent nucleosome remodelling and reversible histone acetylation2,3. The histone deacetylases, however, are unable to deacetylate oligonucleosomal histones in vitro4. The protein complexes that mediate ATP-dependent nucleosome remodelling and histone acetylation/deacetylation in the regulation of transcription were considered to be different, although it has recently been suggested that these activities might be coupled5. We report here the identification and functional characterization of a novel ATP-dependent nucleosome remodelling activity that is part of an endogenous human histone deacetylase complex. This activity is derived from the CHD3 and CHD4 proteins which contain helicase/ATPase domains found in SWI2-related chromatin remodelling factors, and facilitates the deacetylation of oligonucleosomal histones in vitro. We refer to this complex as the nucleosome remodelling and deacetylating (NRD) complex. Our results establish a physical and functional link between the distinct chromatin-modifying activities of histone deacetylases and nucleosome remodelling proteins. More... »

PAGES

917-921

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6705

VOLUME

395

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/27699

DOI

http://dx.doi.org/10.1038/27699

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011958571

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9804427


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