Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1978-12

AUTHORS

Oscar Valbuena, Kenneth B. Marcu, Martin Weigert, Robert P. Perry

ABSTRACT

The number of germline genes specifying the variable sequences of the Vkappa21 group of light chains was determined by saturation hybridisation analysis to be four to six. This gene multiplicity is considerably less than the total variability in the group, indicating that kappa-chain diversity is generated by somatic mutations in both framework and complementarity-determining (hypervariable) regions. More... »

PAGES

780-784

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/276780a0

DOI

http://dx.doi.org/10.1038/276780a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032584407

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/103002


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