Influence of cyclic AMP on intracellular pH regulation and chloride fluxes in barnacle muscle fibres View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1978-11

AUTHORS

WALTER F. BORON, JOHN M. RUSSELL, MALCOLM S. BRODWICK, DAVID W. KEIFER, ALBERT ROOS

ABSTRACT

THE pH sensitivity of numerous intracellular processes requires the close regulation of internal pH (pHi). As the pHi of many cells is maintained at a higher value than it would have if H+ were at equilibrium across the cell membrane, it follows that the acidifying effects of cellular metabolism and of passive H+ influx and HCO−3 efflux must be balanced by active acid extrusion. It is now generally accepted that this extrusion is stimulated by decreases in pHi, and that, in several cells, it is accomplished by exchanging external HCO−3 for internal Cl− (refs 1–4). Recently, a role for cyclic 3′,5′-adenosine monophosphate (cyclic AMP) in pHi regulation was suggested by the observation that dibutyryl cyclic AMP attenuates the CO2-induced fall of pHi in mammalian cardiac muscle5. We now report experiments on the effects of cyclic AMP on acid extrusion and on accompanying Cl− fluxes in the barnacle muscle fibre, a preparation known to contain cyclic AMP (ref. 6). Our data show that internally applied cyclic AMP enhances the response of the pHi-regulating system to acid loads. More... »

PAGES

511

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/276511a0

DOI

http://dx.doi.org/10.1038/276511a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034786400

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31567


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