Sequences from the genome of a non-transforming mutant of polyoma virus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1978-11

AUTHORS

EIICHI SOEDA, BEVERLY E. GRIFFIN

ABSTRACT

POLYOMA, the small DNA animal tumour virus, like the SV40 virus, has attracted interest because its genome is small enough to be analysed at the molecular level1–6, enabling study of the molecular basis of oncogenic transformation. In polyoma virus there are several deletion mutants, designated hr-t (host-range transformation) mutants, which are unable to transform cells (or cause tumours) and which will grow in certain types of cells only, mainly those which have already been transformed. We report here that we have sequenced the region of the DNA which probably determines the non-transforming phenotype of one such hr-t mutant (NG-18)7 and compared it with the sequence of wild-type polyoma virus DNA. These studies show NG-18 to be a frame-shift mutant, and to have lost 187 of the nucleotides present in wild-type DNA, including several nucleotide triplets which code for cysteine. More... »

PAGES

294-298

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/276294a0

DOI

http://dx.doi.org/10.1038/276294a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040970167

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/213731


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyomavirus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Imperial Cancer Research Fund, WC2, Lincoln's Inn Fields, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Imperial Cancer Research Fund, WC2, Lincoln's Inn Fields, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "SOEDA", 
        "givenName": "EIICHI", 
        "id": "sg:person.01347064436.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347064436.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial Cancer Research Fund, WC2, Lincoln's Inn Fields, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Imperial Cancer Research Fund, WC2, Lincoln's Inn Fields, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "GRIFFIN", 
        "givenName": "BEVERLY E.", 
        "id": "sg:person.011477625352.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011477625352.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/273113a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020254632", 
          "https://doi.org/10.1038/273113a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1978-11", 
    "datePublishedReg": "1978-11-01", 
    "description": "POLYOMA, the small DNA animal tumour virus, like the SV40 virus, has attracted interest because its genome is small enough to be analysed at the molecular level1\u20136, enabling study of the molecular basis of oncogenic transformation. In polyoma virus there are several deletion mutants, designated hr-t (host-range transformation) mutants, which are unable to transform cells (or cause tumours) and which will grow in certain types of cells only, mainly those which have already been transformed. We report here that we have sequenced the region of the DNA which probably determines the non-transforming phenotype of one such hr-t mutant (NG-18)7 and compared it with the sequence of wild-type polyoma virus DNA. These studies show NG-18 to be a frame-shift mutant, and to have lost 187 of the nucleotides present in wild-type DNA, including several nucleotide triplets which code for cysteine.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/276294a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5685", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "276"
      }
    ], 
    "keywords": [
      "frame-shift mutant", 
      "non-transforming mutant", 
      "polyoma virus DNA", 
      "animal tumor viruses", 
      "non-transformed phenotype", 
      "polyoma virus", 
      "wild-type DNA", 
      "nucleotide triplets", 
      "deletion mutants", 
      "molecular basis", 
      "oncogenic transformation", 
      "mutants", 
      "tumor virus", 
      "genome", 
      "DNA", 
      "SV40 virus", 
      "NG-18", 
      "sequence", 
      "cells", 
      "virus", 
      "nucleotides", 
      "virus DNA", 
      "polyoma", 
      "phenotype", 
      "cysteine", 
      "region", 
      "certain types", 
      "basis", 
      "study", 
      "types", 
      "triplet", 
      "transformation", 
      "interest", 
      "NG", 
      "code"
    ], 
    "name": "Sequences from the genome of a non-transforming mutant of polyoma virus", 
    "pagination": "294-298", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040970167"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/276294a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "213731"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/276294a0", 
      "https://app.dimensions.ai/details/publication/pub.1040970167"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_108.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/276294a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/276294a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/276294a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/276294a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/276294a0'


 

This table displays all metadata directly associated to this object as RDF triples.

139 TRIPLES      21 PREDICATES      70 URIs      61 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/276294a0 schema:about N2deae96531544292ab1f199e5fe50717
2 N3380a2241aaa4ea4b2b39c3e50e94ee4
3 N43cc04066e4e404eba8b28f5407c6427
4 N719db660f0804ad2937f4904beabed14
5 Nddad4d12d7fe4df98ddb3e5ad8132b3d
6 Ne1d409d9e4d44700a2e48385ee911ce8
7 Nebc6d1ea9b3e43d8809f911ecf8e2a1e
8 Nf24496fbd737424d87a8be8daf09f99c
9 anzsrc-for:06
10 anzsrc-for:0604
11 schema:author N5daf48ed923e4659b7f749961d1f0b2f
12 schema:citation sg:pub.10.1038/273113a0
13 schema:datePublished 1978-11
14 schema:datePublishedReg 1978-11-01
15 schema:description POLYOMA, the small DNA animal tumour virus, like the SV40 virus, has attracted interest because its genome is small enough to be analysed at the molecular level1–6, enabling study of the molecular basis of oncogenic transformation. In polyoma virus there are several deletion mutants, designated hr-t (host-range transformation) mutants, which are unable to transform cells (or cause tumours) and which will grow in certain types of cells only, mainly those which have already been transformed. We report here that we have sequenced the region of the DNA which probably determines the non-transforming phenotype of one such hr-t mutant (NG-18)7 and compared it with the sequence of wild-type polyoma virus DNA. These studies show NG-18 to be a frame-shift mutant, and to have lost 187 of the nucleotides present in wild-type DNA, including several nucleotide triplets which code for cysteine.
16 schema:genre article
17 schema:isAccessibleForFree false
18 schema:isPartOf Na9cbc642b5f84f6d8560c9b5e7a14506
19 Nfa70c2f3a8084c8e86a1400124aa65bb
20 sg:journal.1018957
21 schema:keywords DNA
22 NG
23 NG-18
24 SV40 virus
25 animal tumor viruses
26 basis
27 cells
28 certain types
29 code
30 cysteine
31 deletion mutants
32 frame-shift mutant
33 genome
34 interest
35 molecular basis
36 mutants
37 non-transformed phenotype
38 non-transforming mutant
39 nucleotide triplets
40 nucleotides
41 oncogenic transformation
42 phenotype
43 polyoma
44 polyoma virus
45 polyoma virus DNA
46 region
47 sequence
48 study
49 transformation
50 triplet
51 tumor virus
52 types
53 virus
54 virus DNA
55 wild-type DNA
56 schema:name Sequences from the genome of a non-transforming mutant of polyoma virus
57 schema:pagination 294-298
58 schema:productId N2af78a17f21f4219900d02bdcc05c043
59 N76758315e9a94e1cbdc5785dd874458c
60 Nb8ef49efecc946c397ce3b1645bfd870
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040970167
62 https://doi.org/10.1038/276294a0
63 schema:sdDatePublished 2022-10-01T06:26
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nc253793803094b9593b7a09a57b6b544
66 schema:url https://doi.org/10.1038/276294a0
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N2af78a17f21f4219900d02bdcc05c043 schema:name doi
71 schema:value 10.1038/276294a0
72 rdf:type schema:PropertyValue
73 N2deae96531544292ab1f199e5fe50717 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Polyomavirus
75 rdf:type schema:DefinedTerm
76 N3380a2241aaa4ea4b2b39c3e50e94ee4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Antigens, Viral
78 rdf:type schema:DefinedTerm
79 N39063f94673b4593990ae9d5ba12a49a rdf:first sg:person.011477625352.42
80 rdf:rest rdf:nil
81 N43cc04066e4e404eba8b28f5407c6427 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Mutation
83 rdf:type schema:DefinedTerm
84 N5daf48ed923e4659b7f749961d1f0b2f rdf:first sg:person.01347064436.26
85 rdf:rest N39063f94673b4593990ae9d5ba12a49a
86 N719db660f0804ad2937f4904beabed14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Cell Transformation, Viral
88 rdf:type schema:DefinedTerm
89 N76758315e9a94e1cbdc5785dd874458c schema:name dimensions_id
90 schema:value pub.1040970167
91 rdf:type schema:PropertyValue
92 Na9cbc642b5f84f6d8560c9b5e7a14506 schema:issueNumber 5685
93 rdf:type schema:PublicationIssue
94 Nb8ef49efecc946c397ce3b1645bfd870 schema:name pubmed_id
95 schema:value 213731
96 rdf:type schema:PropertyValue
97 Nc253793803094b9593b7a09a57b6b544 schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 Nddad4d12d7fe4df98ddb3e5ad8132b3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Genes, Viral
101 rdf:type schema:DefinedTerm
102 Ne1d409d9e4d44700a2e48385ee911ce8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Chromosome Deletion
104 rdf:type schema:DefinedTerm
105 Nebc6d1ea9b3e43d8809f911ecf8e2a1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Base Sequence
107 rdf:type schema:DefinedTerm
108 Nf24496fbd737424d87a8be8daf09f99c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Antigens, Neoplasm
110 rdf:type schema:DefinedTerm
111 Nfa70c2f3a8084c8e86a1400124aa65bb schema:volumeNumber 276
112 rdf:type schema:PublicationVolume
113 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
114 schema:name Biological Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
117 schema:name Genetics
118 rdf:type schema:DefinedTerm
119 sg:journal.1018957 schema:issn 0028-0836
120 1476-4687
121 schema:name Nature
122 schema:publisher Springer Nature
123 rdf:type schema:Periodical
124 sg:person.011477625352.42 schema:affiliation grid-institutes:grid.11485.39
125 schema:familyName GRIFFIN
126 schema:givenName BEVERLY E.
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011477625352.42
128 rdf:type schema:Person
129 sg:person.01347064436.26 schema:affiliation grid-institutes:grid.11485.39
130 schema:familyName SOEDA
131 schema:givenName EIICHI
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347064436.26
133 rdf:type schema:Person
134 sg:pub.10.1038/273113a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020254632
135 https://doi.org/10.1038/273113a0
136 rdf:type schema:CreativeWork
137 grid-institutes:grid.11485.39 schema:alternateName Imperial Cancer Research Fund, WC2, Lincoln's Inn Fields, London, UK
138 schema:name Imperial Cancer Research Fund, WC2, Lincoln's Inn Fields, London, UK
139 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...