An intervening sequence of the mouse β-globin major gene shares extensive homology only with β-globin genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1978-10

AUTHORS

H. I. MILLER, D. A. KONKEL, P. LEDER

ABSTRACT

THE mouse β-globin major (βmaj) gene is interrupted by two intervening sequences of DNA that divide it into three discontinuous segments1–3. The entire gene, including the coding, intervening and untranslated regions, is transcribed into a colinear 15S mRNA precursor4 containing a 5′-cap structure and 3′-poly(A) (refs 5–7). Because mature globin mRNA is significantly smaller (10S) and does not contain these intervening sequences, the 15S precursor must be processed. Such processing presumably accounts at least in part for the reduction in sequence length observed between so-called heterogeneous nuclear RNA (Hn RNA) and cytoplasmic RNA8–10. Intervening sequences seem to occur in a variety of genes and organisms1,11–18, but their function and representation in the genome have been unknown. More... »

PAGES

772-774

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/275772a0

DOI

http://dx.doi.org/10.1038/275772a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006669302

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/568218


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Globins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Precursors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20014, Bethesda, Maryland", 
          "id": "http://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20014, Bethesda, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "MILLER", 
        "givenName": "H. I.", 
        "id": "sg:person.01202006741.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202006741.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20014, Bethesda, Maryland", 
          "id": "http://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20014, Bethesda, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "KONKEL", 
        "givenName": "D. A.", 
        "id": "sg:person.01255213767.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255213767.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20014, Bethesda, Maryland", 
          "id": "http://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20014, Bethesda, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LEDER", 
        "givenName": "P.", 
        "id": "sg:person.01160603253.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160603253.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/273349a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044656722", 
          "https://doi.org/10.1038/273349a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1978-10", 
    "datePublishedReg": "1978-10-01", 
    "description": "THE mouse \u03b2-globin major (\u03b2maj) gene is interrupted by two intervening sequences of DNA that divide it into three discontinuous segments1\u20133. The entire gene, including the coding, intervening and untranslated regions, is transcribed into a colinear 15S mRNA precursor4 containing a 5\u2032-cap structure and 3\u2032-poly(A) (refs 5\u20137). Because mature globin mRNA is significantly smaller (10S) and does not contain these intervening sequences, the 15S precursor must be processed. Such processing presumably accounts at least in part for the reduction in sequence length observed between so-called heterogeneous nuclear RNA (Hn RNA) and cytoplasmic RNA8\u201310. Intervening sequences seem to occur in a variety of genes and organisms1,11\u201318, but their function and representation in the genome have been unknown.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/275772a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5682", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "275"
      }
    ], 
    "keywords": [
      "variety of genes", 
      "heterogeneous nuclear RNA", 
      "shares extensive homology", 
      "sequence of DNA", 
      "\u03b2-globin gene", 
      "nuclear RNA", 
      "extensive homology", 
      "entire gene", 
      "major gene", 
      "globin mRNA", 
      "untranslated region", 
      "genes", 
      "sequence", 
      "sequence length", 
      "genome", 
      "homology", 
      "RNA", 
      "DNA", 
      "mRNA", 
      "precursors", 
      "region", 
      "function", 
      "variety", 
      "structure", 
      "length", 
      "part", 
      "reduction", 
      "such processing", 
      "processing", 
      "intervening", 
      "coding", 
      "representation"
    ], 
    "name": "An intervening sequence of the mouse \u03b2-globin major gene shares extensive homology only with \u03b2-globin genes", 
    "pagination": "772-774", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006669302"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/275772a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "568218"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/275772a0", 
      "https://app.dimensions.ai/details/publication/pub.1006669302"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_121.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/275772a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/275772a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/275772a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/275772a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/275772a0'


 

This table displays all metadata directly associated to this object as RDF triples.

143 TRIPLES      21 PREDICATES      67 URIs      58 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/275772a0 schema:about N1089fb6574954465bee46679fcb671bb
2 N1ea071293c02456c813b7b618020c7ed
3 N3ca51d1e934d4b8ebd04016a879c55e0
4 N50df5525a4784ab9a1169862822bf2c7
5 N53a8a7f415f64ba6a935ed789f9687c5
6 N566e2c967f34438e95b9efdeddbd5da3
7 N6a2ac8846b8b486facde97d7afc9b2bb
8 Nc6d0d7cbf9ca4ab08011ee76e45017e1
9 anzsrc-for:06
10 anzsrc-for:0604
11 schema:author N3b7b62e7456a41158cc2f7d3e70fb240
12 schema:citation sg:pub.10.1038/273349a0
13 schema:datePublished 1978-10
14 schema:datePublishedReg 1978-10-01
15 schema:description THE mouse β-globin major (βmaj) gene is interrupted by two intervening sequences of DNA that divide it into three discontinuous segments1–3. The entire gene, including the coding, intervening and untranslated regions, is transcribed into a colinear 15S mRNA precursor4 containing a 5′-cap structure and 3′-poly(A) (refs 5–7). Because mature globin mRNA is significantly smaller (10S) and does not contain these intervening sequences, the 15S precursor must be processed. Such processing presumably accounts at least in part for the reduction in sequence length observed between so-called heterogeneous nuclear RNA (Hn RNA) and cytoplasmic RNA8–10. Intervening sequences seem to occur in a variety of genes and organisms1,11–18, but their function and representation in the genome have been unknown.
16 schema:genre article
17 schema:isAccessibleForFree false
18 schema:isPartOf N12300ba6f3e740ab81a1926ca7032c9b
19 N49efc1035d6b4020ac34d431e5b06e15
20 sg:journal.1018957
21 schema:keywords DNA
22 RNA
23 coding
24 entire gene
25 extensive homology
26 function
27 genes
28 genome
29 globin mRNA
30 heterogeneous nuclear RNA
31 homology
32 intervening
33 length
34 mRNA
35 major gene
36 nuclear RNA
37 part
38 precursors
39 processing
40 reduction
41 region
42 representation
43 sequence
44 sequence length
45 sequence of DNA
46 shares extensive homology
47 structure
48 such processing
49 untranslated region
50 variety
51 variety of genes
52 β-globin gene
53 schema:name An intervening sequence of the mouse β-globin major gene shares extensive homology only with β-globin genes
54 schema:pagination 772-774
55 schema:productId N1a6717f2e0d84177b0503d832c0b5804
56 N4dda6aa28a5a4175b0f3ce7c6c582894
57 Ne9c19d69c1b84ccf967c15ea76f620e2
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006669302
59 https://doi.org/10.1038/275772a0
60 schema:sdDatePublished 2022-12-01T06:17
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N80952b81aac1409daac90c029087dbd9
63 schema:url https://doi.org/10.1038/275772a0
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N1089fb6574954465bee46679fcb671bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Nucleic Acid Conformation
69 rdf:type schema:DefinedTerm
70 N12300ba6f3e740ab81a1926ca7032c9b schema:volumeNumber 275
71 rdf:type schema:PublicationVolume
72 N1a6717f2e0d84177b0503d832c0b5804 schema:name pubmed_id
73 schema:value 568218
74 rdf:type schema:PropertyValue
75 N1ea071293c02456c813b7b618020c7ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Genes
77 rdf:type schema:DefinedTerm
78 N3b7b62e7456a41158cc2f7d3e70fb240 rdf:first sg:person.01202006741.84
79 rdf:rest Nc85ea0d28a3345f7993f68636e5c8a8a
80 N3ca51d1e934d4b8ebd04016a879c55e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Globins
82 rdf:type schema:DefinedTerm
83 N49efc1035d6b4020ac34d431e5b06e15 schema:issueNumber 5682
84 rdf:type schema:PublicationIssue
85 N4dda6aa28a5a4175b0f3ce7c6c582894 schema:name doi
86 schema:value 10.1038/275772a0
87 rdf:type schema:PropertyValue
88 N50df5525a4784ab9a1169862822bf2c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Animals
90 rdf:type schema:DefinedTerm
91 N53a8a7f415f64ba6a935ed789f9687c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Mice
93 rdf:type schema:DefinedTerm
94 N566e2c967f34438e95b9efdeddbd5da3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Base Sequence
96 rdf:type schema:DefinedTerm
97 N6a2ac8846b8b486facde97d7afc9b2bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Nucleic Acid Precursors
99 rdf:type schema:DefinedTerm
100 N80952b81aac1409daac90c029087dbd9 schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 Nc6d0d7cbf9ca4ab08011ee76e45017e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name RNA, Messenger
104 rdf:type schema:DefinedTerm
105 Nc85ea0d28a3345f7993f68636e5c8a8a rdf:first sg:person.01255213767.01
106 rdf:rest Ndcbe011640a54d25b4954a675d0a20de
107 Ndcbe011640a54d25b4954a675d0a20de rdf:first sg:person.01160603253.37
108 rdf:rest rdf:nil
109 Ne9c19d69c1b84ccf967c15ea76f620e2 schema:name dimensions_id
110 schema:value pub.1006669302
111 rdf:type schema:PropertyValue
112 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
113 schema:name Biological Sciences
114 rdf:type schema:DefinedTerm
115 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
116 schema:name Genetics
117 rdf:type schema:DefinedTerm
118 sg:journal.1018957 schema:issn 0028-0836
119 1476-4687
120 schema:name Nature
121 schema:publisher Springer Nature
122 rdf:type schema:Periodical
123 sg:person.01160603253.37 schema:affiliation grid-institutes:grid.420089.7
124 schema:familyName LEDER
125 schema:givenName P.
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160603253.37
127 rdf:type schema:Person
128 sg:person.01202006741.84 schema:affiliation grid-institutes:grid.420089.7
129 schema:familyName MILLER
130 schema:givenName H. I.
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202006741.84
132 rdf:type schema:Person
133 sg:person.01255213767.01 schema:affiliation grid-institutes:grid.420089.7
134 schema:familyName KONKEL
135 schema:givenName D. A.
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255213767.01
137 rdf:type schema:Person
138 sg:pub.10.1038/273349a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044656722
139 https://doi.org/10.1038/273349a0
140 rdf:type schema:CreativeWork
141 grid-institutes:grid.420089.7 schema:alternateName Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20014, Bethesda, Maryland
142 schema:name Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20014, Bethesda, Maryland
143 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...