Molecular basis of base substitution hotspots in Escherichia coli View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1978-08

AUTHORS

Christine Coulondre, Jeffrey H. Miller, Philip J. Farabaugh, Walter Gilbert

ABSTRACT

In the lacI gene of Escherichia coli spontaneous base substituion hotspots occur at 5-methylcytosine residues. The hotspots disappear when the respective cytosines are not methylated. We suggest that the hotspots may result from the spontaneous deamination of 5-methylcytosine to thymine, which is not excised by the enzyme DNA-uracil glycosidase.

PAGES

775-780

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/274775a0

DOI

http://dx.doi.org/10.1038/274775a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012559316

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/355893


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