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        "name": "Biological Sciences", 
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        "type": "DefinedTerm"
      }, 
      {
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        "name": "Circular Dichroism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ethidium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
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        "name": "Models, Biological", 
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      }, 
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        "name": "Nucleic Acid Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotides", 
        "type": "DefinedTerm"
      }, 
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        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligoribonucleotides", 
        "type": "DefinedTerm"
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    "author": [
      {
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          "alternateName": "Chemistry Department and Laboratory of Chemical Biodynamics, University of California, 94720, Berkeley, California", 
          "id": "http://www.grid.ac/institutes/grid.47840.3f", 
          "name": [
            "Chemistry Department and Laboratory of Chemical Biodynamics, University of California, 94720, Berkeley, California"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LEE", 
        "givenName": "CHE-HUNG", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chemistry Department and Laboratory of Chemical Biodynamics, University of California, 94720, Berkeley, California", 
          "id": "http://www.grid.ac/institutes/grid.47840.3f", 
          "name": [
            "Chemistry Department and Laboratory of Chemical Biodynamics, University of California, 94720, Berkeley, California"
          ], 
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    "datePublished": "1978-08", 
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    "description": "ACRIDINES and ethidium are frameshift mutagens1 which intercalate into DNA and RNA2, and into minihelices3,4 made of complementary dinucleotides. However, this intercalation does not provide an explanation of their mutagenic action. Frameshift mutagenesis requires a bulge of one or two bases in either the parent strand (a deletion mutation), or in the newly synthesised strand (an addition mutation). That is, for frameshift mutation to occur, some bases must remain unpaired and outside the normal double helix during replication. We have prepared minihelices containing such bulged bases stabilised by ethidium. Nuclear magnetic resonance (NMR) studies reported here provide strong evidence that a mixture of the oligonucleotides GpUpG plus CpC in the presence of ethidium produces a minihelix containing two G\u00b7C base pairs with the uracil base bulged outside the helix and the ethidium intercalated. Similarly, CpUpG forms minihelices in the presence of ethidium containing bulged bases on both strands. These complexes provide models for the mutagenic action of ethidium.", 
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        "issn": [
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        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5671", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "274"
      }
    ], 
    "keywords": [
      "presence of ethidium", 
      "nuclear magnetic resonance studies", 
      "magnetic resonance studies", 
      "resonance studies", 
      "uracil base", 
      "double helix", 
      "bulged base", 
      "ethidium", 
      "complementary dinucleotides", 
      "complexes", 
      "intercalation", 
      "helix", 
      "acridine", 
      "frameshift mutation", 
      "base pairs", 
      "mixture", 
      "strands", 
      "oligonucleotide", 
      "mutagenic action", 
      "parent strand", 
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      "DNA", 
      "pairs", 
      "strong evidence", 
      "CPC", 
      "replication", 
      "action", 
      "study", 
      "evidence", 
      "explanation", 
      "model", 
      "bulge"
    ], 
    "name": "Mutagen\u2013oligonucleotide complexes with a bulged base as models for frameshift mutation", 
    "pagination": "609-610", 
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    "url": "https://doi.org/10.1038/274609a0"
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