Leptin and the regulation of body weight in mammals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-10

AUTHORS

Jeffrey M. Friedman, Jeffrey L. Halaas

ABSTRACT

The assimilation, storage and use of energy from nutrients constitute a homeostatic system that is essential for life. In vertebrates, the ability to store sufficient quantities of energy-dense triglyceride in adipose tissue allows survival during the frequent periods of food deprivation encountered during evolution. However, the presence of excess adipose tissue can be maladaptive. A complex physiological system has evolved to regulate fuel stores and energy balance at an optimum level. Leptin, a hormone secreted by adipose tissue, and its receptor are integral components of this system. Leptin also signals nutritional status to several other physiological systems and modulates their function. Here we review the role of leptin in the control of body weight and its relevance to the pathogenesis of obesity. More... »

PAGES

763-770

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  • Journal

    TITLE

    Nature

    ISSUE

    6704

    VOLUME

    395

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/27376

    DOI

    http://dx.doi.org/10.1038/27376

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048314480

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9796811


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