Immediate early antigens in human cytomegalovirus infected cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-12

AUTHORS

SUSAN MICHELSON-FISKE, FLORIAN HORODNICEANU, JEAN-CLAUDE GUILLON

ABSTRACT

DURING a comparison of cytomegalovirus (CMV)-specific haemagglutinating and immunofluorescent antibody titres in human sera, 3 of 60 sera tested by indirect immunofluorescence gave homogenous nuclear staining in 100% of infected cells within 1 h after infection (p.i.). These antigens differ from EBNA-type antigens described recently by Geder1 in CMV-infected cells 3 h p.i. in that anticomplement immunofluorescence2 is not required for their detection. They differ from ‘early antigens’ (EA)3 in that they appear much sooner and are located uniquely in the nucleus. Finally, they differ from ‘late antigens’ (LA) for they appear in the absence of DNA synthesis. By analogy to antigens described for the pseudo-rabies system by Ben-Porat et al.4 and for herpes simplex virus type 1 by Beth et al.5, we term these antigens ‘immediate early antigens’ (IEA). More... »

PAGES

615-617

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/270615a0

DOI

http://dx.doi.org/10.1038/270615a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020973711

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/201863


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