Role of non-conventional natural killer cells in resistance against syngeneic tumour cells in vivo View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-12

AUTHORS

O. HALLER, M. HANSSON, R. KIESSLING, H. WIGZELL

ABSTRACT

IMMUNE reactions of ‘conventional’ T and B lymphocytes are generally thought to constitute major parts of any measurable, ‘specific’ tumour resistance against autologous tumours. There is no doubt that protective immunity can be induced against subsequently transplanted syngeneic tumours in experimental systems1. But, there is only scanty evidence to suggest that conventional immune reactions can provide resistance against such tumour cells when transplantation is made into normal individuals. Yet, it is frequently found that even long-transplanted syngeneic tumour cells may require comparatively high numbers of cells to ensure tumour take in normal recipients. Mice failing to succumb to small numbers of tumour cells can frequently be shown to reject a second graft of the same tumour with similar vigour2. Thus, natural resistance against tumours may occur with no display of classical, immunological memory. That such natural protective forces do exist against tumours has been claimed for many years3, but its underlying basis is poorly understood. Here, we present data indicating that naturally occurring killer cells may play a decisive part in providing resistance against syngeneic tumour cells in vivo. More... »

PAGES

609-611

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/270609a0

DOI

http://dx.doi.org/10.1038/270609a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041228119

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/593386


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