Amino acid sequence of Cro regulatory protein of bacteriophage lambda View Full Text


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Article Info

DATE

1977-11

AUTHORS

MYRTLE W. HSIANG, R. DAVID COLE, YOSHINORI TAKEDA, HARRISON ECHOLS

ABSTRACT

THE Cro protein specified by bacteriophage lambda is a repressor of the genes expressed early in phage development; this temporal regulation is required for a normal late stage of lytic growth (see refs 1–5). Cro protein has been purified and shown to bind to the operator regions, OL and OR6,7, used by the cI repressor protein to maintain lysogeny8; purified Cro also represses RNA synthesis initiated at the early promoter sites on λ DNA7. Among the features that make Cro interesting for further biochemical study are its timed physiological action1–5 and apparent role in regulation of DNA replication9. Cro is also convenient for structural analysis because of its extremely small size6,7. Here we report the amino acid sequence of Cro protein. More... »

PAGES

275-277

References to SciGraph publications

  • 1975. Sequence Determination in PROTEIN SEQUENCE DETERMINATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/270275a0

    DOI

    http://dx.doi.org/10.1038/270275a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035305734

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/593348


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