Sequence of cro gene of bacteriophage lambda View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-11

AUTHORS

THO M. ROBERTS, HIROYUKI SHIMATAKE, CATHERINE BRADY, MIN ROSENBERG

ABSTRACT

KNOWLEDGE of the primary sequences of represser proteins and the DNA operators with which they interact is essential for detailed study of the molecular aspects of the control of gene expression. The sequences of two repressers are known: the cI protein of lambda (ref. 1 and R. Sauer and R. Anderegg, personal communication) and the i gene product of the lactose operon of Escherichia coli (refs 2,3 and P. J. Farabaugh, personal communication). Here we report the DNA sequence for the structural gene of a third represser, the Cro protein of lambda. This protein is of special interest both because of its small size (66 amino acids, as compared with the 236 amino acids of the cI protein and the 360 amino acids of the lac i gene), and because genetic evidence suggests that it interacts with the same operator regions as does the cI protein, although the two proteins probably do not recognise exactly the same DNA bases4–7. More... »

PAGES

274-275

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/270274a0

DOI

http://dx.doi.org/10.1038/270274a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038189031

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/593347


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