Synchronised transmembrane insertion and glycosylation of a nascent membrane protein View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-10

AUTHORS

James E. Rothman, Harvey F. Lodish

ABSTRACT

Studies of the synthesis and incorporation of the vesicular stomatitis virus glycoprotein into membranes in a synchronised cell-free system demonstrate a tight coupling between polypeptide synthesis and membrane insertion, as a result of which the nascent chain crosses the membrane. The studies reveal a surprisingly precise sequence by which the nascent chain of this membrane glycoprotein is glycosylated in two steps. These findings have important implications for the mechanisms of membrane assembly. More... »

PAGES

775-780

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/269775a0

DOI

http://dx.doi.org/10.1038/269775a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034555844

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/200844


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