Ontology type: schema:ScholarlyArticle Open Access: True
1977-09
AUTHORS ABSTRACTCELL membrane structures controlled by genes in the major histocompatibility complex (H–2 in mice) are involved in most immune interactions between T lymphocytes and other cells1. Cytotoxic T lymphocytes (CTL) immunised against viruses2, haptens3, minor histocompatibility antigens4 or tumour antigens5, are specific for self H–2 antigens as well as for the foreign antigen. But CTL are not restricted to recognising antigens in combination with only self H–2. H–2d homozygous CTL which have matured in an irradiated H–2d/H–2k host can respond to antigen plus H–2k in addition to antigen plus H–2d (refs 6–8). It is not known whether the H–2 environment in which T cells mature influences their range of specificity, that is, whether CTL from a normal mouse can respond quantitatively as well to antigen plus foreign H–2 as they do to antigen plus self H–2. These experiments were designed to test this influence. The results suggest that host H–2 antigens do exert an effect on the specificity of T-cell responses. More... »
PAGES417-418
http://scigraph.springernature.com/pub.10.1038/269417a0
DOIhttp://dx.doi.org/10.1038/269417a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1034526188
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/302918
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cytotoxicity, Immunologic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "H-2 Antigens",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunity, Cellular",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred Strains",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiation Chimera",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spleen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "T-Lymphocytes",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 02139, Cambridge, Massachusetts",
"id": "http://www.grid.ac/institutes/grid.116068.8",
"name": [
"Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 02139, Cambridge, Massachusetts"
],
"type": "Organization"
},
"familyName": "BEVAN",
"givenName": "MICHAEL J.",
"id": "sg:person.016506100262.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016506100262.17"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/260250a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008384120",
"https://doi.org/10.1038/260250a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01572293",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021913666",
"https://doi.org/10.1007/bf01572293"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/261141a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039140796",
"https://doi.org/10.1038/261141a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/261139a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030286094",
"https://doi.org/10.1038/261139a0"
],
"type": "CreativeWork"
}
],
"datePublished": "1977-09",
"datePublishedReg": "1977-09-01",
"description": "CELL membrane structures controlled by genes in the major histocompatibility complex (H\u20132 in mice) are involved in most immune interactions between T lymphocytes and other cells1. Cytotoxic T lymphocytes (CTL) immunised against viruses2, haptens3, minor histocompatibility antigens4 or tumour antigens5, are specific for self H\u20132 antigens as well as for the foreign antigen. But CTL are not restricted to recognising antigens in combination with only self H\u20132. H\u20132d homozygous CTL which have matured in an irradiated H\u20132d/H\u20132k host can respond to antigen plus H\u20132k in addition to antigen plus H\u20132d (refs 6\u20138). It is not known whether the H\u20132 environment in which T cells mature influences their range of specificity, that is, whether CTL from a normal mouse can respond quantitatively as well to antigen plus foreign H\u20132 as they do to antigen plus self H\u20132. These experiments were designed to test this influence. The results suggest that host H\u20132 antigens do exert an effect on the specificity of T-cell responses.",
"genre": "article",
"id": "sg:pub.10.1038/269417a0",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "5627",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "269"
}
],
"keywords": [
"cytotoxic T lymphocytes",
"self H",
"major histocompatibility complex",
"host H",
"immune responsiveness",
"T lymphocytes",
"foreign antigens",
"normal mice",
"immune interactions",
"radiation chimaeras",
"cell responses",
"antigen",
"histocompatibility complex",
"range of specificities",
"lymphocytes",
"cell membrane structure",
"specificity",
"mice",
"responsiveness",
"cytotoxic",
"Cells1",
"cells",
"response",
"membrane structure",
"genes",
"chimaeras",
"effect",
"host",
"combination",
"addition",
"influence",
"results",
"complexes",
"interaction",
"range",
"structure",
"environment",
"experiments"
],
"name": "In a radiation chimaera, host H\u20132 antigens determine immune responsiveness of donor cytotoxic cells",
"pagination": "417-418",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1034526188"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/269417a0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"302918"
]
}
],
"sameAs": [
"https://doi.org/10.1038/269417a0",
"https://app.dimensions.ai/details/publication/pub.1034526188"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T09:38",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_109.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/269417a0"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/269417a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/269417a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/269417a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/269417a0'
This table displays all metadata directly associated to this object as RDF triples.
151 TRIPLES
21 PREDICATES
77 URIs
65 LITERALS
16 BLANK NODES