Reduced β-adrenergic receptor concentrations in ageing man View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-06

AUTHORS

D. D. SCHOCKEN, G. S. ROTH

ABSTRACT

CONCENTRATIONS of certain hormone receptors are known to be reduced during ageing in several animal species1–4. Most relevant work, however, has been limited to intracellular hormone receptors such as those for steroids, and less is known about changes in cell surface receptors, including those for catecholamines. We have measured the concentration of β-adrenergic receptors in crude membrane fractions of mononuclear cells from human subjects of various ages. Receptor affinities for (—)3H-dihydroal-prenolol were esentially the same for all subjects. But a significant decrease in receptor concentration was observed in cells from older individuals. More... »

PAGES

856-858

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/267856a0

DOI

http://dx.doi.org/10.1038/267856a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042523748

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/197415


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