Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-10

AUTHORS

Lucas Waltzer, Mariann Bienz

ABSTRACT

T-cell factor (TCF), a high-mobility-group domain protein, is the transcription factor activated by Wnt/Wingless signalling. When signalling occurs, TCF binds to its coactivator, beta-catenin/Armadillo, and stimulates the transcription of the target genes of Wnt/Wingless by binding to TCF-responsive enhancers. Inappropriate activation of TCF in the colon epithelium and other cells leads to cancer. It is therefore desirable for unstimulated cells to have a negative control mechanism to keep TCF inactive. Here we report that Drosophila CREB-binding protein (dCBP) binds to dTCF. dCBP mutants show mild Wingless overactivation phenotypes in various tissues. Consistent with this, dCBP loss-of-function suppresses the effects of armadillo mutation. Moreover, our data show that dCBP acetylates a conserved lysine in the Armadillo-binding domain of dTCF, and that this acetylation lowers the affinity of Armadillo binding to dTCF. Although CBP is a coactivator of other transcription factors, our data show that CBP represses TCF. More... »

PAGES

521

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/26785

DOI

http://dx.doi.org/10.1038/26785

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026674370

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9774110


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