Steroid–nucleosides possible novel agents for cancer chemotherapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-06

AUTHORS

J. E. VAN LIER, G. KAN, D. AUTENRIETH, V. N. NIGAM

ABSTRACT

THE major classes of anti-cancer chemotherapeutic drugs include alkylating agents, anti-metabolites of nucleic acids, steroid hormones and antibiotics1. Because of the lack of specificity of anti-tumour agents, attempts have been made to increase their specificity and cell-penetrating properties by coupling them to steroid hormones2,3. In particular, steroidal alkylating agents exhibit carcinostatic properties if used in combination with other modes of therapy4. We have prepared a novel class of agents by coupling steroids with naturally occurring purines and pyrimidines by way of a C–N linkage. The structures are unique in that they may be regarded as analogues both of steroid hormones and of ‘nucleosides’ in which the sugar has been replaced. Accordingly, we may expect their steroid moiety to provide target specificity, while their nucleoside characteristics may result in interference at the DNA level to give the desired anti-tumour activity. Preliminary studies on the effect of steroid–nucleosides on the lifespan of tumour-bearing animals show that selectively coupled products exhibit anti-tumour activity. More... »

PAGES

522

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/267522a0

DOI

http://dx.doi.org/10.1038/267522a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023990002

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/876369


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