β Endorphin inhibits ACh turnover in nuclei of rat brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-05

AUTHORS

D. L. CHENEY, E. COSTA, F. MORONI

ABSTRACT

NARCOTIC drugs modify cholinergic mechanisms in central and peripheral nervous systems1, and analgesic doses of morphine, meperidine, viminol R2 and azidomorphine decrease acetylcholine (ACh) turnover rate (TRAch) in selected brain nuclei2,3. This suggests that endogenous opiate receptor agonists regulate cholinergic mechanisms in some brain nuclei2. Among the endogenous opiate receptor agonists, β endorphin is particularly interesting because it is more active than morphine in causing analgesia and catalepsy4. This polypeptide and α endorphin share some structural similarities which correspond to fragments 61–76 and 61–91 of β lipotropin, respectively5. We have investigated whether α and β endorphin also mimic the action of morphine on TRACh of selected brain nuclei. We have found that analgesic doses of β endorphin injected intraventricularly decrease TRACh in cortex, hippocampus, nucleus accumbens and globus pallidus but not in nucleus caudatus. This decrease of TRACh was antagonised by naltrexone. In contrast, α endorphin failed to cause analgesia or to decrease TRACh in all brain nuclei studied. More... »

PAGES

267

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/267267a0

DOI

http://dx.doi.org/10.1038/267267a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010770515

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/865620


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