Nitroso group exchange as a way of activation of nitrosamines by bacteria View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-05

AUTHORS

M. MANDEL, D. ICHINOTSUBO, H. MOWER

ABSTRACT

MUTAGENIC compounds and most carcinogens are thought to interact either directly or through metabolic activation processes with DNA to alter and damage the double helical structure. Bacteria defective in some aspect of DNA repair or recombination are in general much more sensitive to mutagenic and carcinogenic agents than the parent strains. Several bacterial test systems1,2 have been developed to assay for carcinogenic activity based on the premise that most carcinogens are mutagens in the proper conditions. One of the most widely used bacterial screening systems has been developed by Ames et al.1 based on mutational reversion to prototrophy of a sensitive strain of Salmonella typhimurium. We have developed a screening system using rec− Escherichia coli based on the lethal nature of unrepaired DNA3–5. More... »

PAGES

248

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/267248a0

DOI

http://dx.doi.org/10.1038/267248a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008333753

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/325417


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