Heterosynaptic depression: a postsynaptic correlate of long-term potentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-04

AUTHORS

G. S. LYNCH, T. DUNWIDDIE, V. GRIBKOFF

ABSTRACT

BRIEF trains of electrical stimulation delivered to any one of several hippocampal pathways often result in immediate and long-lasting enhancement of subsequent postsynaptic responses elicited by that pathway1–5. The unusual characteristics of these effects suggest that theories of long-term potentiation (specifically changes in transmitter release by the presynaptic terminal) which have evolved from work on invertebrate and neuromusclar preparations may not be appropriate to explain synaptic plasticity in hippocampus. We report here the results of experiments intended to examine the postsynaptic consequences of repetitive stimulation. We found that potentiation of one afferent tended to depress the target cell's responses to a second test input. More... »

PAGES

737-739

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/266737a0

DOI

http://dx.doi.org/10.1038/266737a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003287611

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/195211


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