Induction of tolerance to the analgesic action of lipotropin C-Fragment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1976-12

AUTHORS

J. M. VAN REE, D. DE WIED, A. F. BRADBURY, E. C. HULME, D. G. YTH, C. R. SNELL

ABSTRACT

THE C-Fragment of β-lipotropin (lipotropin 61-91), was first discovered as an intact peptide in the pituitary gland1,2 and it has recently been shown to be present in brain3. The peptide binds strongly to brain opiate receptors in vitro4,5 and has potent opiate-like actions on the guinea pig ileum and mouse vas deferens15. Reports from our laboratory described the potent analgesic properties of C-Fragment when injected into the cerebral ventricles of the cat4–6, and in subsequent studies its analgesic effects have been demonstrated in rodents7–9. The results reported here confirm the analgesic potency of C-Fragment administered intracerebrally in the rat, and show that chronic administration of the peptide leads to the development of tolerance to its analgesic actions. More... »

PAGES

792-794

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/264792a0

DOI

http://dx.doi.org/10.1038/264792a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019925050

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1012322


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