Single ionic channels induced in lipid bilayers by polyene antibiotics amphotericin B and nystatine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1976-08

AUTHORS

L. N. ERMISHKIN, Kh. M. KASUMOV, V. M. POTZELUYEV

ABSTRACT

AMPHOTERICIN B and nystatine increase the permeability of lipid membranes to ions, water and non-electrolytes1,2. Cholesterol (or some other sterols) is a necessary membrane component for the antibiotics to be effective1,3. Permeability to water and non-electrolytes increases linearly with ion permeability2. The molecules of the size of glucose and larger are essentially impermeant. It is concluded2,4 that amphotericin B and nystatine form aqueous pores with an effective radius of approximately 4 Å in thin lipid membranes. The changes in membrane conductance connected with the formation of a single pore have, however, not yet been observed. In this paper the properties of individual conductance channels induced in black lipid membranes by amphotericin B and nystatine are described briefly. More... »

PAGES

698-699

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/262698a0

DOI

http://dx.doi.org/10.1038/262698a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045561900

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/958440


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Chemistry (incl. Structural)", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amphotericin B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electric Conductivity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membranes, Artificial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nystatin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Physics, Azerb. SSR Academy of Sciences, Baku, USSR", 
          "id": "http://www.grid.ac/institutes/grid.435347.2", 
          "name": [
            "Institute of Biological Physics, USSR Academy of Sciences, Pushchino, Moscow Region", 
            "Institute of Physics, Azerb. SSR Academy of Sciences, Baku, USSR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "ERMISHKIN", 
        "givenName": "L. N.", 
        "id": "sg:person.0107736041.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0107736041.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Physics, Azerb. SSR Academy of Sciences, Baku, USSR", 
          "id": "http://www.grid.ac/institutes/grid.435347.2", 
          "name": [
            "Institute of Biological Physics, USSR Academy of Sciences, Pushchino, Moscow Region", 
            "Institute of Physics, Azerb. SSR Academy of Sciences, Baku, USSR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "KASUMOV", 
        "givenName": "Kh. M.", 
        "id": "sg:person.0113170344.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113170344.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Physics, Azerb. SSR Academy of Sciences, Baku, USSR", 
          "id": "http://www.grid.ac/institutes/grid.435347.2", 
          "name": [
            "Institute of Biological Physics, USSR Academy of Sciences, Pushchino, Moscow Region", 
            "Institute of Physics, Azerb. SSR Academy of Sciences, Baku, USSR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "POTZELUYEV", 
        "givenName": "V. M.", 
        "type": "Person"
      }
    ], 
    "datePublished": "1976-08", 
    "datePublishedReg": "1976-08-01", 
    "description": "AMPHOTERICIN B and nystatine increase the permeability of lipid membranes to ions, water and non-electrolytes1,2. Cholesterol (or some other sterols) is a necessary membrane component for the antibiotics to be effective1,3. Permeability to water and non-electrolytes increases linearly with ion permeability2. The molecules of the size of glucose and larger are essentially impermeant. It is concluded2,4 that amphotericin B and nystatine form aqueous pores with an effective radius of approximately 4 \u00c5 in thin lipid membranes. The changes in membrane conductance connected with the formation of a single pore have, however, not yet been observed. In this paper the properties of individual conductance channels induced in black lipid membranes by amphotericin B and nystatine are described briefly.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/262698a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5570", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "262"
      }
    ], 
    "keywords": [
      "lipid membranes", 
      "thin lipid membranes", 
      "black lipid membranes", 
      "polyene antibiotic amphotericin B", 
      "antibiotic amphotericin B", 
      "membrane components", 
      "lipid bilayers", 
      "aqueous pores", 
      "single pore", 
      "conductance channel", 
      "membrane", 
      "pores", 
      "water", 
      "single ionic channels", 
      "ions", 
      "ionic channels", 
      "molecules", 
      "membrane conductance", 
      "bilayers", 
      "permeability", 
      "properties", 
      "formation", 
      "amphotericin B", 
      "conductance", 
      "effective radius", 
      "glucose", 
      "channels", 
      "size", 
      "antibiotics", 
      "components", 
      "nystatine", 
      "radius", 
      "changes", 
      "cholesterol", 
      "Non", 
      "paper"
    ], 
    "name": "Single ionic channels induced in lipid bilayers by polyene antibiotics amphotericin B and nystatine", 
    "pagination": "698-699", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045561900"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/262698a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "958440"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/262698a0", 
      "https://app.dimensions.ai/details/publication/pub.1045561900"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_129.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/262698a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/262698a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/262698a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/262698a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/262698a0'


 

This table displays all metadata directly associated to this object as RDF triples.

143 TRIPLES      20 PREDICATES      70 URIs      60 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/262698a0 schema:about N18bd2de849de4db1abeb9fb51f290396
2 N42bea5c5dacf4b89b49a4e64971a0e90
3 N4f07bb869d3646df878424b46030e430
4 Ne118514fb13449d2a26c671afe0f37a0
5 Ned502ce53f734722b234973ac4c9edf4
6 Nf038415fa04b4cee9fa035a36fdb20eb
7 anzsrc-for:03
8 anzsrc-for:0306
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author Ncd3edbc853f84224a0743334bb3669ee
12 schema:datePublished 1976-08
13 schema:datePublishedReg 1976-08-01
14 schema:description AMPHOTERICIN B and nystatine increase the permeability of lipid membranes to ions, water and non-electrolytes1,2. Cholesterol (or some other sterols) is a necessary membrane component for the antibiotics to be effective1,3. Permeability to water and non-electrolytes increases linearly with ion permeability2. The molecules of the size of glucose and larger are essentially impermeant. It is concluded2,4 that amphotericin B and nystatine form aqueous pores with an effective radius of approximately 4 Å in thin lipid membranes. The changes in membrane conductance connected with the formation of a single pore have, however, not yet been observed. In this paper the properties of individual conductance channels induced in black lipid membranes by amphotericin B and nystatine are described briefly.
15 schema:genre article
16 schema:isAccessibleForFree false
17 schema:isPartOf N501ed553d13449439e4aad4c9b7ec15f
18 Nf147fd8063dc40e0b0296a5ec943735f
19 sg:journal.1018957
20 schema:keywords Non
21 amphotericin B
22 antibiotic amphotericin B
23 antibiotics
24 aqueous pores
25 bilayers
26 black lipid membranes
27 changes
28 channels
29 cholesterol
30 components
31 conductance
32 conductance channel
33 effective radius
34 formation
35 glucose
36 ionic channels
37 ions
38 lipid bilayers
39 lipid membranes
40 membrane
41 membrane components
42 membrane conductance
43 molecules
44 nystatine
45 paper
46 permeability
47 polyene antibiotic amphotericin B
48 pores
49 properties
50 radius
51 single ionic channels
52 single pore
53 size
54 thin lipid membranes
55 water
56 schema:name Single ionic channels induced in lipid bilayers by polyene antibiotics amphotericin B and nystatine
57 schema:pagination 698-699
58 schema:productId N47150c96bfb949b59892d7afbf80dbec
59 Nd66b6a1b31c5469c8ed4cb21c57221d6
60 Ne24d910581584e9a9d9381c1ae5539b0
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045561900
62 https://doi.org/10.1038/262698a0
63 schema:sdDatePublished 2022-09-02T15:45
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N3b095f72450849d4986cbd9deddb95ff
66 schema:url https://doi.org/10.1038/262698a0
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N181c6c041eed4f65be5c7e3ea55e4d7d schema:affiliation grid-institutes:grid.435347.2
71 schema:familyName POTZELUYEV
72 schema:givenName V. M.
73 rdf:type schema:Person
74 N18bd2de849de4db1abeb9fb51f290396 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Nystatin
76 rdf:type schema:DefinedTerm
77 N3b095f72450849d4986cbd9deddb95ff schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N42bea5c5dacf4b89b49a4e64971a0e90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Electric Conductivity
81 rdf:type schema:DefinedTerm
82 N47150c96bfb949b59892d7afbf80dbec schema:name doi
83 schema:value 10.1038/262698a0
84 rdf:type schema:PropertyValue
85 N4f07bb869d3646df878424b46030e430 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Ions
87 rdf:type schema:DefinedTerm
88 N501ed553d13449439e4aad4c9b7ec15f schema:volumeNumber 262
89 rdf:type schema:PublicationVolume
90 Nc2e8108ac0e94b0fb7da4b9321088572 rdf:first sg:person.0113170344.42
91 rdf:rest Nfd38096eb40f49c18b5340ec7564e000
92 Ncd3edbc853f84224a0743334bb3669ee rdf:first sg:person.0107736041.99
93 rdf:rest Nc2e8108ac0e94b0fb7da4b9321088572
94 Nd66b6a1b31c5469c8ed4cb21c57221d6 schema:name dimensions_id
95 schema:value pub.1045561900
96 rdf:type schema:PropertyValue
97 Ne118514fb13449d2a26c671afe0f37a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Membrane Potentials
99 rdf:type schema:DefinedTerm
100 Ne24d910581584e9a9d9381c1ae5539b0 schema:name pubmed_id
101 schema:value 958440
102 rdf:type schema:PropertyValue
103 Ned502ce53f734722b234973ac4c9edf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Membranes, Artificial
105 rdf:type schema:DefinedTerm
106 Nf038415fa04b4cee9fa035a36fdb20eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Amphotericin B
108 rdf:type schema:DefinedTerm
109 Nf147fd8063dc40e0b0296a5ec943735f schema:issueNumber 5570
110 rdf:type schema:PublicationIssue
111 Nfd38096eb40f49c18b5340ec7564e000 rdf:first N181c6c041eed4f65be5c7e3ea55e4d7d
112 rdf:rest rdf:nil
113 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
114 schema:name Chemical Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:0306 schema:inDefinedTermSet anzsrc-for:
117 schema:name Physical Chemistry (incl. Structural)
118 rdf:type schema:DefinedTerm
119 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
120 schema:name Biological Sciences
121 rdf:type schema:DefinedTerm
122 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
123 schema:name Biochemistry and Cell Biology
124 rdf:type schema:DefinedTerm
125 sg:journal.1018957 schema:issn 0028-0836
126 1476-4687
127 schema:name Nature
128 schema:publisher Springer Nature
129 rdf:type schema:Periodical
130 sg:person.0107736041.99 schema:affiliation grid-institutes:grid.435347.2
131 schema:familyName ERMISHKIN
132 schema:givenName L. N.
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0107736041.99
134 rdf:type schema:Person
135 sg:person.0113170344.42 schema:affiliation grid-institutes:grid.435347.2
136 schema:familyName KASUMOV
137 schema:givenName Kh. M.
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113170344.42
139 rdf:type schema:Person
140 grid-institutes:grid.435347.2 schema:alternateName Institute of Physics, Azerb. SSR Academy of Sciences, Baku, USSR
141 schema:name Institute of Biological Physics, USSR Academy of Sciences, Pushchino, Moscow Region
142 Institute of Physics, Azerb. SSR Academy of Sciences, Baku, USSR
143 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...