DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1976-03

AUTHORS

D. STEHELIN, H. E. VARMUS, J. M. BISHOP, P. K. VOGT

ABSTRACT

INFECTION of fibroblasts by avian sarcoma virus (ASV) leads to neoplastic transformation of the host cell. Genetic analyses have implicated specific viral genes in the transforming process1–4, and recent results suggest that a single viral gene is responsible4. Normal chicken cells contain DNA homologous to part of the ASV genome5–8; moreover, embryonic fibroblasts from certain strains of chickens can produce low titres of infectious type C viruses either spontaneously9 or in response to various inducing agents10. None of the viruses obtained from normal chicken cells, however, can transform fibroblasts, and results with molecular hybridisation indicate that the nucleotide sequences responsible for transformation by ASV are not part of the genetic complement of the normal cell11. We demonstrate here that the DNA of normal chicken cells contains nucleotide sequences closely related to at least a portion of the transforming gene(s) of ASV; in addition, we have found that similar sequences are widely distributed among DNA of avian species and that they have diverged roughly according to phylogenetic distances among the species. Our data are relevant to current hypotheses of the origin of the genomes of RNA tumour viruses12 and the potential role of these genomes in oncogenesis13. More... »

PAGES

170-173

Journal

TITLE

Nature

ISSUE

5547

VOLUME

260

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/260170a0

    DOI

    http://dx.doi.org/10.1038/260170a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019128532

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/176594


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