Unrelated animal viruses share receptors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1976-02

AUTHORS

K. LONBERG-HOLM, R. L. CROWELL, L. PHILIPSON

ABSTRACT

THE specific receptors for several non-enveloped viruses are present on cells in only limited numbers (1 × 104–10 × 104), and can therefore be saturated with excess virus1–5. An excess of inactivated poliovirus type 1 inhibits the attachment of infectious poliovirus of all 3 serotypes, but not the attachment of other viruses, including B Coxsackie viruses6. Most of the B Coxsackie viruses probably share the same receptor7, but Coxsackie viruses B1 and B3 do not compete for the poliovirus receptor1. Adenovirus 2 and 5 also appear to share the same receptor, since their attachment to host cells is blocked by an excess of the adenovirus type 2 fibre protein, which seems to be the receptor-recognising portion of the virus particle2. A number of other adenoviruses may also belong to the same receptor family since soluble antigens block their attachment to erythrocytes8. We here report results which permit the construction of a ‘receptor map’ for a number of non-enveloped viruses. More... »

PAGES

679-681

Journal

TITLE

Nature

ISSUE

5545

VOLUME

259

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/259679a0

DOI

http://dx.doi.org/10.1038/259679a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002679698

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/175292


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