Ontology type: schema:ScholarlyArticle
1976-01
AUTHORS ABSTRACTMACROPHAGES can have critical roles in repair, inflammation and a large variety of immunological phenomena1,2. The biological roles of these cells often occur subsequent to their ‘activation’, a subjective term which refers to a greatly heightened state of reactivity1–3. Activation can be induced by a variety of stimuli including ingestion of certain macro-organisms, contact with immune complexes, bacterial lipopolysaccharides and lymphokines3. Activated macrophages usually show an increase in cell size, increased adherence properties and cellular processes, lysosomal enzyme activity, and phagocytic ability1,2. In addition, alteration in characteristics and functions of various macrophage receptors can apparently take place as a consequence of activation4,5. Such a change is described in this paper: it involves Fc receptors as detected by Fc or EA rosette formation (see Table 1), and their relationship to surface mouse major histocompatibility (H–2) antigens as detected by anti-H–2 alloantisera. Aside from the general relevance this change has with regard to membrane alterations which occur in activated lymphoreticular cells, it can also be exploited as a marker for activated macrophages. More... »
PAGES226-228
http://scigraph.springernature.com/pub.10.1038/259226a0
DOIhttp://dx.doi.org/10.1038/259226a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1019372472
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/1250350
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antigen-Antibody Reactions",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cytotoxicity Tests, Immunologic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Histocompatibility Antigens",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immune Adherence Reaction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunoglobulin Fc Fragments",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Macrophages",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Division of Cancer Research, Department of Pathology, Queen's University, Kingston, Ontario, Canada",
"id": "http://www.grid.ac/institutes/grid.410356.5",
"name": [
"Division of Cancer Research, Department of Pathology, Queen's University, Kingston, Ontario, Canada"
],
"type": "Organization"
},
"familyName": "KERBEL",
"givenName": "ROBERT S.",
"id": "sg:person.0673064574.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673064574.73"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/250342a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007549089",
"https://doi.org/10.1038/250342a0"
],
"type": "CreativeWork"
}
],
"datePublished": "1976-01",
"datePublishedReg": "1976-01-01",
"description": "MACROPHAGES can have critical roles in repair, inflammation and a large variety of immunological phenomena1,2. The biological roles of these cells often occur subsequent to their \u2018activation\u2019, a subjective term which refers to a greatly heightened state of reactivity1\u20133. Activation can be induced by a variety of stimuli including ingestion of certain macro-organisms, contact with immune complexes, bacterial lipopolysaccharides and lymphokines3. Activated macrophages usually show an increase in cell size, increased adherence properties and cellular processes, lysosomal enzyme activity, and phagocytic ability1,2. In addition, alteration in characteristics and functions of various macrophage receptors can apparently take place as a consequence of activation4,5. Such a change is described in this paper: it involves Fc receptors as detected by Fc or EA rosette formation (see Table 1), and their relationship to surface mouse major histocompatibility (H\u20132) antigens as detected by anti-H\u20132 alloantisera. Aside from the general relevance this change has with regard to membrane alterations which occur in activated lymphoreticular cells, it can also be exploited as a marker for activated macrophages.",
"genre": "article",
"id": "sg:pub.10.1038/259226a0",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "5540",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "259"
}
],
"keywords": [
"antibody-mediated cytotoxicity",
"EA rosette formation",
"lysosomal enzyme activity",
"rosette inhibition",
"lymphoreticular cells",
"immune complexes",
"major histocompatibility",
"Fc receptors",
"mouse major histocompatibility",
"variety of stimuli",
"rosette formation",
"bacterial lipopolysaccharide",
"Activated macrophages",
"macrophages",
"macrophage receptor",
"receptors",
"membrane alterations",
"adherence properties",
"alterations",
"critical role",
"activation",
"biological role",
"cells",
"inflammation",
"enzyme activity",
"histocompatibility",
"lipopolysaccharide",
"alloantisera",
"ingestion",
"inhibition",
"markers",
"role",
"repair",
"cytotoxicity",
"stimuli",
"cellular processes",
"changes",
"FC",
"activity",
"cell size",
"increase",
"relevance",
"resistance",
"subjective terms",
"regard",
"variety",
"function",
"addition",
"consequences",
"relationship",
"contact",
"general relevance",
"characteristics",
"large variety",
"size",
"formation",
"complexes",
"state",
"place",
"terms",
"process",
"properties",
"paper"
],
"name": "Resistance of activated macrophages to H\u20132 antibody-mediated cytotoxicity and Fc rosette inhibition",
"pagination": "226-228",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1019372472"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/259226a0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"1250350"
]
}
],
"sameAs": [
"https://doi.org/10.1038/259226a0",
"https://app.dimensions.ai/details/publication/pub.1019372472"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T09:39",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_139.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/259226a0"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/259226a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/259226a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/259226a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/259226a0'
This table displays all metadata directly associated to this object as RDF triples.
172 TRIPLES
21 PREDICATES
101 URIs
90 LITERALS
16 BLANK NODES
Subject | Predicate | Object | |
---|---|---|---|
1 | sg:pub.10.1038/259226a0 | schema:about | N2402e9cd10b243449dd4923d68819ca8 |
2 | ″ | ″ | N2429a2a06ae74fc2829e834fd0fd5389 |
3 | ″ | ″ | N446f5a158e0e4a028b169be5a59010cf |
4 | ″ | ″ | N57a1cdc653204df59fab0e4755a80c1b |
5 | ″ | ″ | N769a6785239a4858b3a5795db80ef9ba |
6 | ″ | ″ | N7fa2fa75b81b47388f20bfe05d2f4971 |
7 | ″ | ″ | Ne5718774c0f64888adf5d05f0b00aa06 |
8 | ″ | ″ | Nf7686cc952da4835b7a584836ed88a7c |
9 | ″ | ″ | Nfd334b37118b4136bce73c6703747d62 |
10 | ″ | ″ | anzsrc-for:06 |
11 | ″ | ″ | anzsrc-for:0601 |
12 | ″ | ″ | anzsrc-for:11 |
13 | ″ | ″ | anzsrc-for:1107 |
14 | ″ | schema:author | N4eb30eaf112b4e06ac9aca30ae7aabb3 |
15 | ″ | schema:citation | sg:pub.10.1038/250342a0 |
16 | ″ | schema:datePublished | 1976-01 |
17 | ″ | schema:datePublishedReg | 1976-01-01 |
18 | ″ | schema:description | MACROPHAGES can have critical roles in repair, inflammation and a large variety of immunological phenomena1,2. The biological roles of these cells often occur subsequent to their ‘activation’, a subjective term which refers to a greatly heightened state of reactivity1–3. Activation can be induced by a variety of stimuli including ingestion of certain macro-organisms, contact with immune complexes, bacterial lipopolysaccharides and lymphokines3. Activated macrophages usually show an increase in cell size, increased adherence properties and cellular processes, lysosomal enzyme activity, and phagocytic ability1,2. In addition, alteration in characteristics and functions of various macrophage receptors can apparently take place as a consequence of activation4,5. Such a change is described in this paper: it involves Fc receptors as detected by Fc or EA rosette formation (see Table 1), and their relationship to surface mouse major histocompatibility (H–2) antigens as detected by anti-H–2 alloantisera. Aside from the general relevance this change has with regard to membrane alterations which occur in activated lymphoreticular cells, it can also be exploited as a marker for activated macrophages. |
19 | ″ | schema:genre | article |
20 | ″ | schema:isAccessibleForFree | false |
21 | ″ | schema:isPartOf | N51a30e16e6bb4f71952519982ce8bf49 |
22 | ″ | ″ | N7cfedf9bd9e14448b6444e1058cd4916 |
23 | ″ | ″ | sg:journal.1018957 |
24 | ″ | schema:keywords | Activated macrophages |
25 | ″ | ″ | EA rosette formation |
26 | ″ | ″ | FC |
27 | ″ | ″ | Fc receptors |
28 | ″ | ″ | activation |
29 | ″ | ″ | activity |
30 | ″ | ″ | addition |
31 | ″ | ″ | adherence properties |
32 | ″ | ″ | alloantisera |
33 | ″ | ″ | alterations |
34 | ″ | ″ | antibody-mediated cytotoxicity |
35 | ″ | ″ | bacterial lipopolysaccharide |
36 | ″ | ″ | biological role |
37 | ″ | ″ | cell size |
38 | ″ | ″ | cells |
39 | ″ | ″ | cellular processes |
40 | ″ | ″ | changes |
41 | ″ | ″ | characteristics |
42 | ″ | ″ | complexes |
43 | ″ | ″ | consequences |
44 | ″ | ″ | contact |
45 | ″ | ″ | critical role |
46 | ″ | ″ | cytotoxicity |
47 | ″ | ″ | enzyme activity |
48 | ″ | ″ | formation |
49 | ″ | ″ | function |
50 | ″ | ″ | general relevance |
51 | ″ | ″ | histocompatibility |
52 | ″ | ″ | immune complexes |
53 | ″ | ″ | increase |
54 | ″ | ″ | inflammation |
55 | ″ | ″ | ingestion |
56 | ″ | ″ | inhibition |
57 | ″ | ″ | large variety |
58 | ″ | ″ | lipopolysaccharide |
59 | ″ | ″ | lymphoreticular cells |
60 | ″ | ″ | lysosomal enzyme activity |
61 | ″ | ″ | macrophage receptor |
62 | ″ | ″ | macrophages |
63 | ″ | ″ | major histocompatibility |
64 | ″ | ″ | markers |
65 | ″ | ″ | membrane alterations |
66 | ″ | ″ | mouse major histocompatibility |
67 | ″ | ″ | paper |
68 | ″ | ″ | place |
69 | ″ | ″ | process |
70 | ″ | ″ | properties |
71 | ″ | ″ | receptors |
72 | ″ | ″ | regard |
73 | ″ | ″ | relationship |
74 | ″ | ″ | relevance |
75 | ″ | ″ | repair |
76 | ″ | ″ | resistance |
77 | ″ | ″ | role |
78 | ″ | ″ | rosette formation |
79 | ″ | ″ | rosette inhibition |
80 | ″ | ″ | size |
81 | ″ | ″ | state |
82 | ″ | ″ | stimuli |
83 | ″ | ″ | subjective terms |
84 | ″ | ″ | terms |
85 | ″ | ″ | variety |
86 | ″ | ″ | variety of stimuli |
87 | ″ | schema:name | Resistance of activated macrophages to H–2 antibody-mediated cytotoxicity and Fc rosette inhibition |
88 | ″ | schema:pagination | 226-228 |
89 | ″ | schema:productId | N2b77394767a5411696be17f13e2ba13c |
90 | ″ | ″ | Ne26574eb1a434d829a1c89b0adecae0e |
91 | ″ | ″ | Nfbdfc1aca1a74bf9abfaab55e72e4976 |
92 | ″ | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1019372472 |
93 | ″ | ″ | https://doi.org/10.1038/259226a0 |
94 | ″ | schema:sdDatePublished | 2022-05-10T09:39 |
95 | ″ | schema:sdLicense | https://scigraph.springernature.com/explorer/license/ |
96 | ″ | schema:sdPublisher | N6d8a84dc0ae740bea44f861621260147 |
97 | ″ | schema:url | https://doi.org/10.1038/259226a0 |
98 | ″ | sgo:license | sg:explorer/license/ |
99 | ″ | sgo:sdDataset | articles |
100 | ″ | rdf:type | schema:ScholarlyArticle |
101 | N2402e9cd10b243449dd4923d68819ca8 | schema:inDefinedTermSet | https://www.nlm.nih.gov/mesh/ |
102 | ″ | schema:name | Mice |
103 | ″ | rdf:type | schema:DefinedTerm |
104 | N2429a2a06ae74fc2829e834fd0fd5389 | schema:inDefinedTermSet | https://www.nlm.nih.gov/mesh/ |
105 | ″ | schema:name | Lymphocytes |
106 | ″ | rdf:type | schema:DefinedTerm |
107 | N2b77394767a5411696be17f13e2ba13c | schema:name | dimensions_id |
108 | ″ | schema:value | pub.1019372472 |
109 | ″ | rdf:type | schema:PropertyValue |
110 | N446f5a158e0e4a028b169be5a59010cf | schema:inDefinedTermSet | https://www.nlm.nih.gov/mesh/ |
111 | ″ | schema:name | Cytotoxicity Tests, Immunologic |
112 | ″ | rdf:type | schema:DefinedTerm |
113 | N4eb30eaf112b4e06ac9aca30ae7aabb3 | rdf:first | sg:person.0673064574.73 |
114 | ″ | rdf:rest | rdf:nil |
115 | N51a30e16e6bb4f71952519982ce8bf49 | schema:issueNumber | 5540 |
116 | ″ | rdf:type | schema:PublicationIssue |
117 | N57a1cdc653204df59fab0e4755a80c1b | schema:inDefinedTermSet | https://www.nlm.nih.gov/mesh/ |
118 | ″ | schema:name | Immunoglobulin Fc Fragments |
119 | ″ | rdf:type | schema:DefinedTerm |
120 | N6d8a84dc0ae740bea44f861621260147 | schema:name | Springer Nature - SN SciGraph project |
121 | ″ | rdf:type | schema:Organization |
122 | N769a6785239a4858b3a5795db80ef9ba | schema:inDefinedTermSet | https://www.nlm.nih.gov/mesh/ |
123 | ″ | schema:name | Histocompatibility Antigens |
124 | ″ | rdf:type | schema:DefinedTerm |
125 | N7cfedf9bd9e14448b6444e1058cd4916 | schema:volumeNumber | 259 |
126 | ″ | rdf:type | schema:PublicationVolume |
127 | N7fa2fa75b81b47388f20bfe05d2f4971 | schema:inDefinedTermSet | https://www.nlm.nih.gov/mesh/ |
128 | ″ | schema:name | Antigen-Antibody Reactions |
129 | ″ | rdf:type | schema:DefinedTerm |
130 | Ne26574eb1a434d829a1c89b0adecae0e | schema:name | pubmed_id |
131 | ″ | schema:value | 1250350 |
132 | ″ | rdf:type | schema:PropertyValue |
133 | Ne5718774c0f64888adf5d05f0b00aa06 | schema:inDefinedTermSet | https://www.nlm.nih.gov/mesh/ |
134 | ″ | schema:name | Macrophages |
135 | ″ | rdf:type | schema:DefinedTerm |
136 | Nf7686cc952da4835b7a584836ed88a7c | schema:inDefinedTermSet | https://www.nlm.nih.gov/mesh/ |
137 | ″ | schema:name | Immune Adherence Reaction |
138 | ″ | rdf:type | schema:DefinedTerm |
139 | Nfbdfc1aca1a74bf9abfaab55e72e4976 | schema:name | doi |
140 | ″ | schema:value | 10.1038/259226a0 |
141 | ″ | rdf:type | schema:PropertyValue |
142 | Nfd334b37118b4136bce73c6703747d62 | schema:inDefinedTermSet | https://www.nlm.nih.gov/mesh/ |
143 | ″ | schema:name | Animals |
144 | ″ | rdf:type | schema:DefinedTerm |
145 | anzsrc-for:06 | schema:inDefinedTermSet | anzsrc-for: |
146 | ″ | schema:name | Biological Sciences |
147 | ″ | rdf:type | schema:DefinedTerm |
148 | anzsrc-for:0601 | schema:inDefinedTermSet | anzsrc-for: |
149 | ″ | schema:name | Biochemistry and Cell Biology |
150 | ″ | rdf:type | schema:DefinedTerm |
151 | anzsrc-for:11 | schema:inDefinedTermSet | anzsrc-for: |
152 | ″ | schema:name | Medical and Health Sciences |
153 | ″ | rdf:type | schema:DefinedTerm |
154 | anzsrc-for:1107 | schema:inDefinedTermSet | anzsrc-for: |
155 | ″ | schema:name | Immunology |
156 | ″ | rdf:type | schema:DefinedTerm |
157 | sg:journal.1018957 | schema:issn | 0028-0836 |
158 | ″ | ″ | 1476-4687 |
159 | ″ | schema:name | Nature |
160 | ″ | schema:publisher | Springer Nature |
161 | ″ | rdf:type | schema:Periodical |
162 | sg:person.0673064574.73 | schema:affiliation | grid-institutes:grid.410356.5 |
163 | ″ | schema:familyName | KERBEL |
164 | ″ | schema:givenName | ROBERT S. |
165 | ″ | schema:sameAs | https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673064574.73 |
166 | ″ | rdf:type | schema:Person |
167 | sg:pub.10.1038/250342a0 | schema:sameAs | https://app.dimensions.ai/details/publication/pub.1007549089 |
168 | ″ | ″ | https://doi.org/10.1038/250342a0 |
169 | ″ | rdf:type | schema:CreativeWork |
170 | grid-institutes:grid.410356.5 | schema:alternateName | Division of Cancer Research, Department of Pathology, Queen's University, Kingston, Ontario, Canada |
171 | ″ | schema:name | Division of Cancer Research, Department of Pathology, Queen's University, Kingston, Ontario, Canada |
172 | ″ | rdf:type | schema:Organization |