Resistance of activated macrophages to H–2 antibody-mediated cytotoxicity and Fc rosette inhibition View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1976-01

AUTHORS

ROBERT S. KERBEL

ABSTRACT

MACROPHAGES can have critical roles in repair, inflammation and a large variety of immunological phenomena1,2. The biological roles of these cells often occur subsequent to their ‘activation’, a subjective term which refers to a greatly heightened state of reactivity1–3. Activation can be induced by a variety of stimuli including ingestion of certain macro-organisms, contact with immune complexes, bacterial lipopolysaccharides and lymphokines3. Activated macrophages usually show an increase in cell size, increased adherence properties and cellular processes, lysosomal enzyme activity, and phagocytic ability1,2. In addition, alteration in characteristics and functions of various macrophage receptors can apparently take place as a consequence of activation4,5. Such a change is described in this paper: it involves Fc receptors as detected by Fc or EA rosette formation (see Table 1), and their relationship to surface mouse major histocompatibility (H–2) antigens as detected by anti-H–2 alloantisera. Aside from the general relevance this change has with regard to membrane alterations which occur in activated lymphoreticular cells, it can also be exploited as a marker for activated macrophages. More... »

PAGES

226-228

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/259226a0

DOI

http://dx.doi.org/10.1038/259226a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019372472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1250350


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