Troponin C in brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-11

AUTHORS

RICHARD FINE, WILLIAM LEHMAN, JAMES HEAD, ALAN BLITZ

ABSTRACT

THE tropomyosin–troponin complex renders actomyosin from vertebrate skeletal muscle calcium sensitive. Troponin itself consists of three subunits: troponin I (TNI), troponin C (TNC) and troponin T (TNT)1. Pure TNI (24,000-dalton subunit) inhibits the actin–myosin interaction irrespective of calcium concentration. TNC (18,000-dalton subunit) binds calcium and releases the TNI imposed inhibition. TNT (37,000-dalton subunit) attaches the subunit complex to tropomyosin. Actin, myosin and tropomyosin have been isolated and characterised from a number of non-muscle cells2,3. We now describe the isolation and characterisation of a protein from chick embryo brain which is very similar to muscle TNC. More... »

PAGES

260-262

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/258260a0

DOI

http://dx.doi.org/10.1038/258260a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001533395

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1202358


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chick Embryo", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Troponin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Physiology, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts", 
          "id": "http://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Physiology, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts"
          ], 
          "type": "Organization"
        }, 
        "familyName": "FINE", 
        "givenName": "RICHARD", 
        "id": "sg:person.0771573710.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771573710.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts", 
          "id": "http://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Physiology, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LEHMAN", 
        "givenName": "WILLIAM", 
        "id": "sg:person.01325246337.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325246337.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts", 
          "id": "http://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Physiology, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts"
          ], 
          "type": "Organization"
        }, 
        "familyName": "HEAD", 
        "givenName": "JAMES", 
        "id": "sg:person.01243437571.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243437571.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts", 
          "id": "http://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Physiology, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts"
          ], 
          "type": "Organization"
        }, 
        "familyName": "BLITZ", 
        "givenName": "ALAN", 
        "id": "sg:person.0112541461.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0112541461.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/newbio234115a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025874654", 
          "https://doi.org/10.1038/newbio234115a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/255424a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048991098", 
          "https://doi.org/10.1038/255424a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1975-11", 
    "datePublishedReg": "1975-11-01", 
    "description": "THE tropomyosin\u2013troponin complex renders actomyosin from vertebrate skeletal muscle calcium sensitive. Troponin itself consists of three subunits: troponin I (TNI), troponin C (TNC) and troponin T (TNT)1. Pure TNI (24,000-dalton subunit) inhibits the actin\u2013myosin interaction irrespective of calcium concentration. TNC (18,000-dalton subunit) binds calcium and releases the TNI imposed inhibition. TNT (37,000-dalton subunit) attaches the subunit complex to tropomyosin. Actin, myosin and tropomyosin have been isolated and characterised from a number of non-muscle cells2,3. We now describe the isolation and characterisation of a protein from chick embryo brain which is very similar to muscle TNC.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/258260a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5532", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "258"
      }
    ], 
    "keywords": [
      "troponin I", 
      "skeletal muscle calcium", 
      "chick embryo brain", 
      "muscle calcium", 
      "troponin T", 
      "calcium concentration", 
      "embryo brain", 
      "troponin C", 
      "brain", 
      "calcium", 
      "bind calcium", 
      "troponin", 
      "myosin interaction", 
      "inhibition", 
      "tropomyosin", 
      "actin", 
      "protein", 
      "myosin", 
      "concentration", 
      "subunits", 
      "subunit complex", 
      "isolation", 
      "number", 
      "actomyosin", 
      "interaction", 
      "TNT", 
      "complexes", 
      "characterisation", 
      "tropomyosin\u2013troponin complex renders actomyosin", 
      "complex renders actomyosin", 
      "renders actomyosin", 
      "vertebrate skeletal muscle calcium", 
      "Pure TNI", 
      "TNC (18,000-dalton subunit) binds calcium"
    ], 
    "name": "Troponin C in brain", 
    "pagination": "260-262", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001533395"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/258260a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1202358"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/258260a0", 
      "https://app.dimensions.ai/details/publication/pub.1001533395"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_128.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/258260a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/258260a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/258260a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/258260a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/258260a0'


 

This table displays all metadata directly associated to this object as RDF triples.

148 TRIPLES      21 PREDICATES      68 URIs      58 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/258260a0 schema:about N21f1990edc984e08a4284309d71a5cdd
2 N51f65d9988d8407c8c1bc3daf2725f7d
3 Na7d3c90ac5b24ec6b7a6493c39972539
4 Nb472ad3d219747c499b88493bca646e8
5 Nb78aae2b65be4281a48925cf62fef455
6 Nc43fca8605fd407c973a1b2f65e38e53
7 anzsrc-for:11
8 anzsrc-for:1109
9 schema:author N3f24b5839e634a76b5265bdedf5cdb27
10 schema:citation sg:pub.10.1038/255424a0
11 sg:pub.10.1038/newbio234115a0
12 schema:datePublished 1975-11
13 schema:datePublishedReg 1975-11-01
14 schema:description THE tropomyosin–troponin complex renders actomyosin from vertebrate skeletal muscle calcium sensitive. Troponin itself consists of three subunits: troponin I (TNI), troponin C (TNC) and troponin T (TNT)1. Pure TNI (24,000-dalton subunit) inhibits the actin–myosin interaction irrespective of calcium concentration. TNC (18,000-dalton subunit) binds calcium and releases the TNI imposed inhibition. TNT (37,000-dalton subunit) attaches the subunit complex to tropomyosin. Actin, myosin and tropomyosin have been isolated and characterised from a number of non-muscle cells2,3. We now describe the isolation and characterisation of a protein from chick embryo brain which is very similar to muscle TNC.
15 schema:genre article
16 schema:isAccessibleForFree false
17 schema:isPartOf N1eff3970444b49288579ba97a682aa82
18 Nc16448fd5f144a298e43802c76426583
19 sg:journal.1018957
20 schema:keywords Pure TNI
21 TNC (18,000-dalton subunit) binds calcium
22 TNT
23 actin
24 actomyosin
25 bind calcium
26 brain
27 calcium
28 calcium concentration
29 characterisation
30 chick embryo brain
31 complex renders actomyosin
32 complexes
33 concentration
34 embryo brain
35 inhibition
36 interaction
37 isolation
38 muscle calcium
39 myosin
40 myosin interaction
41 number
42 protein
43 renders actomyosin
44 skeletal muscle calcium
45 subunit complex
46 subunits
47 tropomyosin
48 tropomyosin–troponin complex renders actomyosin
49 troponin
50 troponin C
51 troponin I
52 troponin T
53 vertebrate skeletal muscle calcium
54 schema:name Troponin C in brain
55 schema:pagination 260-262
56 schema:productId N02700f8b49a841d385d2e50bd875f0cf
57 N4a4819557ba94f748eeebf539ec6595e
58 Nc36a8753c51f4f9dacc83a1d0f703439
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001533395
60 https://doi.org/10.1038/258260a0
61 schema:sdDatePublished 2022-01-01T18:01
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N0c77534f921e471d83ede2d0a741e1f0
64 schema:url https://doi.org/10.1038/258260a0
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N02700f8b49a841d385d2e50bd875f0cf schema:name pubmed_id
69 schema:value 1202358
70 rdf:type schema:PropertyValue
71 N0c77534f921e471d83ede2d0a741e1f0 schema:name Springer Nature - SN SciGraph project
72 rdf:type schema:Organization
73 N1eff3970444b49288579ba97a682aa82 schema:volumeNumber 258
74 rdf:type schema:PublicationVolume
75 N21f1990edc984e08a4284309d71a5cdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Brain Chemistry
77 rdf:type schema:DefinedTerm
78 N3f24b5839e634a76b5265bdedf5cdb27 rdf:first sg:person.0771573710.58
79 rdf:rest Nc30d7280bd0e4ba2b774492da673e155
80 N4a4819557ba94f748eeebf539ec6595e schema:name dimensions_id
81 schema:value pub.1001533395
82 rdf:type schema:PropertyValue
83 N51f65d9988d8407c8c1bc3daf2725f7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Troponin
85 rdf:type schema:DefinedTerm
86 Na7d3c90ac5b24ec6b7a6493c39972539 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Muscle Proteins
88 rdf:type schema:DefinedTerm
89 Nb472ad3d219747c499b88493bca646e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Amino Acids
91 rdf:type schema:DefinedTerm
92 Nb78aae2b65be4281a48925cf62fef455 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Animals
94 rdf:type schema:DefinedTerm
95 Nbda07a0582a14b5dadeed516e24935e3 rdf:first sg:person.0112541461.38
96 rdf:rest rdf:nil
97 Nc16448fd5f144a298e43802c76426583 schema:issueNumber 5532
98 rdf:type schema:PublicationIssue
99 Nc30d7280bd0e4ba2b774492da673e155 rdf:first sg:person.01325246337.01
100 rdf:rest Nf5ad94b08250426a99a56cf1e210bfb7
101 Nc36a8753c51f4f9dacc83a1d0f703439 schema:name doi
102 schema:value 10.1038/258260a0
103 rdf:type schema:PropertyValue
104 Nc43fca8605fd407c973a1b2f65e38e53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Chick Embryo
106 rdf:type schema:DefinedTerm
107 Nf5ad94b08250426a99a56cf1e210bfb7 rdf:first sg:person.01243437571.24
108 rdf:rest Nbda07a0582a14b5dadeed516e24935e3
109 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
110 schema:name Medical and Health Sciences
111 rdf:type schema:DefinedTerm
112 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
113 schema:name Neurosciences
114 rdf:type schema:DefinedTerm
115 sg:journal.1018957 schema:issn 0028-0836
116 1476-4687
117 schema:name Nature
118 schema:publisher Springer Nature
119 rdf:type schema:Periodical
120 sg:person.0112541461.38 schema:affiliation grid-institutes:grid.189504.1
121 schema:familyName BLITZ
122 schema:givenName ALAN
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0112541461.38
124 rdf:type schema:Person
125 sg:person.01243437571.24 schema:affiliation grid-institutes:grid.189504.1
126 schema:familyName HEAD
127 schema:givenName JAMES
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243437571.24
129 rdf:type schema:Person
130 sg:person.01325246337.01 schema:affiliation grid-institutes:grid.189504.1
131 schema:familyName LEHMAN
132 schema:givenName WILLIAM
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325246337.01
134 rdf:type schema:Person
135 sg:person.0771573710.58 schema:affiliation grid-institutes:grid.189504.1
136 schema:familyName FINE
137 schema:givenName RICHARD
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771573710.58
139 rdf:type schema:Person
140 sg:pub.10.1038/255424a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048991098
141 https://doi.org/10.1038/255424a0
142 rdf:type schema:CreativeWork
143 sg:pub.10.1038/newbio234115a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025874654
144 https://doi.org/10.1038/newbio234115a0
145 rdf:type schema:CreativeWork
146 grid-institutes:grid.189504.1 schema:alternateName Department of Physiology, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts
147 schema:name Department of Physiology, Boston University School of Medicine, 80 East Concord Street, 02118, Boston, Massachusetts
148 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...