Three-dimensional segregation of supramolecular activation clusters in T cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-09

AUTHORS

Colin R. F. Monks, Benjamin A. Freiberg, Hannah Kupfer, Noah Sciaky, Abraham Kupfer

ABSTRACT

Activation of T cells by antigen-presenting cells (APCs) depends on the complex integration of signals that are delivered by multiple antigen receptors. Most receptor-proximal activation events in T cells1,2 were identified using multivalent anti-receptor antibodies, eliminating the need to use the more complex APCs. As the physiological membrane-associated ligands on the APC and the activating antibodies probably trigger the same biochemical pathways, it is unknown why the antibodies, even at saturating concentrations, fail to trigger some of the physiological T-cell responses3. Here we study, at the level of the single cell, the responses of T cells to native ligands. We used a digital imaging system and analysed the three-dimensional distribution of receptors and intracellular proteins that cluster at the contacts between T cells and APCs during antigen-specific interactions3,4. Surprisingly, instead of showing uniform oligomerization, these proteins clustered into segregated three-dimensional domains within the cell contacts. The antigen-specific formation of these new, spatially segregated supramolecular activation clusters may generate appropriate physiological responses and may explain the high sensitivity of the T cells to antigen. More... »

PAGES

82-86

Journal

TITLE

Nature

ISSUE

6697

VOLUME

395

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/25764

    DOI

    http://dx.doi.org/10.1038/25764

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001596774

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9738502


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