Isolation and properties of a murine spleen cell Fc receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-09

AUTHORS

LARS RASK, LARS KLARESKOG, LARS ÖSTBERG, PER A. PETERSON

ABSTRACT

MURINE and human bone marrow-derived (B) lymphocytes have a cell surface-bound receptor for antibody complexed to antigen. Heat-aggregated immunoglobulin complexes will also bind to this receptor, and the binding is specifically mediated by means of the Fc portion of the IgG molecule1–3. So far, the only function ascribed to the Fc receptor is in the antibody-dependent lymphocyte-mediated cytotoxicity reaction3. A recent report has indicated, however, that the Fc receptor is identical to or closely associated with the Ia antigens on the B-cell membrane4. The Ia antigens are alloantigens coded for by the immune response region of the major histocompatibility complex5 and if indeed these antigens and the Fc receptor are identical, this would reveal a role for the receptor in several aspects of the immune response6. More... »

PAGES

231-233

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/257231a0

DOI

http://dx.doi.org/10.1038/257231a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015995722

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/51477


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