Immunologically-mediated restraint of latent tumour metastases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-09

AUTHORS

SUZANNE A. ECCLES, P. ALEXANDER

ABSTRACT

DIFFERENT grafted sarcomas, all originally from chemically-induced autochthonous tumours, vary widely in their capacity to form metastases, as determined by the incidence of secondaries which appear in the lung and lymph nodes in the months following surgical removal of the ‘primary’ transplant from syngeneic rats1. Tumours which do not form metastases readily in normal animals can be induced to do so by grafting into syngeneic rats depleted of T lymphocytes by procedures which do not compromise the bone marrow1. We concluded that specific immune processes requiring the participation of T lymphocytes contributed to the control of metastatic spread—possibly by reducing the number of tumour cells released because there is an inverse relationship between the number of macrophages within the tumour and metastasis1,2. In addition, circulating tumour cells may be destroyed immunologically and an immunologically-specific factor that acted against intravenously-injected sarcoma cells was demonstrated in the serum and lymph of tumour-bearing rats3,4. More... »

PAGES

52

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/257052a0

DOI

http://dx.doi.org/10.1038/257052a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046469364

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1080544


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunity, Cellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunosuppression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Node Excision", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoma, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "ECCLES", 
        "givenName": "SUZANNE A.", 
        "id": "sg:person.016313524317.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016313524317.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "ALEXANDER", 
        "givenName": "P.", 
        "id": "sg:person.01035011131.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035011131.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/250667a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022657242", 
          "https://doi.org/10.1038/250667a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/242029a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042142956", 
          "https://doi.org/10.1038/242029a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074743184", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080549253", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1975-09", 
    "datePublishedReg": "1975-09-01", 
    "description": "DIFFERENT grafted sarcomas, all originally from chemically-induced autochthonous tumours, vary widely in their capacity to form metastases, as determined by the incidence of secondaries which appear in the lung and lymph nodes in the months following surgical removal of the \u2018primary\u2019 transplant from syngeneic rats1. Tumours which do not form metastases readily in normal animals can be induced to do so by grafting into syngeneic rats depleted of T lymphocytes by procedures which do not compromise the bone marrow1. We concluded that specific immune processes requiring the participation of T lymphocytes contributed to the control of metastatic spread\u2014possibly by reducing the number of tumour cells released because there is an inverse relationship between the number of macrophages within the tumour and metastasis1,2. In addition, circulating tumour cells may be destroyed immunologically and an immunologically-specific factor that acted against intravenously-injected sarcoma cells was demonstrated in the serum and lymph of tumour-bearing rats3,4.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/257052a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5521", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "257"
      }
    ], 
    "name": "Immunologically-mediated restraint of latent tumour metastases", 
    "pagination": "52", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dd5c9c4836a737455fce4ce1c4be9103f573b8e582b5962fef684ce24d5456ca"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1080544"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/257052a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046469364"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/257052a0", 
      "https://app.dimensions.ai/details/publication/pub.1046469364"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/257052a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/257052a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/257052a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/257052a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/257052a0'


 

This table displays all metadata directly associated to this object as RDF triples.

123 TRIPLES      21 PREDICATES      43 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/257052a0 schema:about N5b1a46236b3f4ecb9363aac3768ea75b
2 N7746e74707a24b818e7ee9b04bd3fbb1
3 N9506fc8342f940f9a32f53e20d7b1d18
4 Nbc22431665aa4b2e82fea76fda8ff199
5 Nd6940f1658fd45ad80400129b3c3f61a
6 Ne36344e582a14af9904f535e5c6bac9f
7 Nf0b1dedd29f04145b1b7fa11fc037bdc
8 Nf40c7ed39dd3438486aa44dcc561eed9
9 Nf9df08fb9f7a4cd48d5136dae5988f22
10 Nfa239cf6142040a995354ca78c639a48
11 anzsrc-for:11
12 anzsrc-for:1107
13 schema:author N2a400b591ab847519be6d6ba2ae78bb5
14 schema:citation sg:pub.10.1038/242029a0
15 sg:pub.10.1038/250667a0
16 https://app.dimensions.ai/details/publication/pub.1074743184
17 https://app.dimensions.ai/details/publication/pub.1080549253
18 schema:datePublished 1975-09
19 schema:datePublishedReg 1975-09-01
20 schema:description DIFFERENT grafted sarcomas, all originally from chemically-induced autochthonous tumours, vary widely in their capacity to form metastases, as determined by the incidence of secondaries which appear in the lung and lymph nodes in the months following surgical removal of the ‘primary’ transplant from syngeneic rats1. Tumours which do not form metastases readily in normal animals can be induced to do so by grafting into syngeneic rats depleted of T lymphocytes by procedures which do not compromise the bone marrow1. We concluded that specific immune processes requiring the participation of T lymphocytes contributed to the control of metastatic spread—possibly by reducing the number of tumour cells released because there is an inverse relationship between the number of macrophages within the tumour and metastasis1,2. In addition, circulating tumour cells may be destroyed immunologically and an immunologically-specific factor that acted against intravenously-injected sarcoma cells was demonstrated in the serum and lymph of tumour-bearing rats3,4.
21 schema:genre research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree false
24 schema:isPartOf N20aed8dcfaf14ef1a35a4577ba4f469c
25 Ne286d1c1890f4be18907183cc4e96c35
26 sg:journal.1018957
27 schema:name Immunologically-mediated restraint of latent tumour metastases
28 schema:pagination 52
29 schema:productId N3dde2216e14844d68517ee0268500f09
30 N93c2459326ee4bdeab6712228f226ee6
31 Na3ef6a4b023947789284dc74a243c36b
32 Nb5c1fa0cfa6546ebb980f1ba5bcd79ab
33 Nb6f35b58f4274b17ab665f0da4bc3145
34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046469364
35 https://doi.org/10.1038/257052a0
36 schema:sdDatePublished 2019-04-10T14:48
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher N50a6bd676ae14b30aa9f9798c2d397ce
39 schema:url https://www.nature.com/articles/257052a0
40 sgo:license sg:explorer/license/
41 sgo:sdDataset articles
42 rdf:type schema:ScholarlyArticle
43 N20aed8dcfaf14ef1a35a4577ba4f469c schema:issueNumber 5521
44 rdf:type schema:PublicationIssue
45 N2a400b591ab847519be6d6ba2ae78bb5 rdf:first sg:person.016313524317.09
46 rdf:rest N9bbe2365bae74ca3ac116c3f9e41c490
47 N3dde2216e14844d68517ee0268500f09 schema:name doi
48 schema:value 10.1038/257052a0
49 rdf:type schema:PropertyValue
50 N50a6bd676ae14b30aa9f9798c2d397ce schema:name Springer Nature - SN SciGraph project
51 rdf:type schema:Organization
52 N5b1a46236b3f4ecb9363aac3768ea75b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
53 schema:name Animals
54 rdf:type schema:DefinedTerm
55 N7746e74707a24b818e7ee9b04bd3fbb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Neoplasm Metastasis
57 rdf:type schema:DefinedTerm
58 N93c2459326ee4bdeab6712228f226ee6 schema:name dimensions_id
59 schema:value pub.1046469364
60 rdf:type schema:PropertyValue
61 N9506fc8342f940f9a32f53e20d7b1d18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Immunity, Cellular
63 rdf:type schema:DefinedTerm
64 N9bbe2365bae74ca3ac116c3f9e41c490 rdf:first sg:person.01035011131.52
65 rdf:rest rdf:nil
66 Na3ef6a4b023947789284dc74a243c36b schema:name readcube_id
67 schema:value dd5c9c4836a737455fce4ce1c4be9103f573b8e582b5962fef684ce24d5456ca
68 rdf:type schema:PropertyValue
69 Nb5c1fa0cfa6546ebb980f1ba5bcd79ab schema:name pubmed_id
70 schema:value 1080544
71 rdf:type schema:PropertyValue
72 Nb6f35b58f4274b17ab665f0da4bc3145 schema:name nlm_unique_id
73 schema:value 0410462
74 rdf:type schema:PropertyValue
75 Nbc22431665aa4b2e82fea76fda8ff199 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Lymph Node Excision
77 rdf:type schema:DefinedTerm
78 Nd6940f1658fd45ad80400129b3c3f61a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Immunosuppression
80 rdf:type schema:DefinedTerm
81 Ne286d1c1890f4be18907183cc4e96c35 schema:volumeNumber 257
82 rdf:type schema:PublicationVolume
83 Ne36344e582a14af9904f535e5c6bac9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Lymphatic Metastasis
85 rdf:type schema:DefinedTerm
86 Nf0b1dedd29f04145b1b7fa11fc037bdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Sarcoma, Experimental
88 rdf:type schema:DefinedTerm
89 Nf40c7ed39dd3438486aa44dcc561eed9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Lung Neoplasms
91 rdf:type schema:DefinedTerm
92 Nf9df08fb9f7a4cd48d5136dae5988f22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name T-Lymphocytes
94 rdf:type schema:DefinedTerm
95 Nfa239cf6142040a995354ca78c639a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Rats
97 rdf:type schema:DefinedTerm
98 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
99 schema:name Medical and Health Sciences
100 rdf:type schema:DefinedTerm
101 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
102 schema:name Immunology
103 rdf:type schema:DefinedTerm
104 sg:journal.1018957 schema:issn 0090-0028
105 1476-4687
106 schema:name Nature
107 rdf:type schema:Periodical
108 sg:person.01035011131.52 schema:familyName ALEXANDER
109 schema:givenName P.
110 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035011131.52
111 rdf:type schema:Person
112 sg:person.016313524317.09 schema:familyName ECCLES
113 schema:givenName SUZANNE A.
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016313524317.09
115 rdf:type schema:Person
116 sg:pub.10.1038/242029a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042142956
117 https://doi.org/10.1038/242029a0
118 rdf:type schema:CreativeWork
119 sg:pub.10.1038/250667a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022657242
120 https://doi.org/10.1038/250667a0
121 rdf:type schema:CreativeWork
122 https://app.dimensions.ai/details/publication/pub.1074743184 schema:CreativeWork
123 https://app.dimensions.ai/details/publication/pub.1080549253 schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...