1975-08
AUTHORSR. J. RUSSELL, P. C. WILKINSON, F. SLESS, DELPHINE M. V. PARROTT
ABSTRACTLYMPHOCYTES are motile cells whose movement in vivo seems to be directed, yet investigators over many years have repeatedly failed to show chemotaxis of lymphocytes in vitro. There have been some recent reports that lymphocytes migrate into micropore filters towards substances placed below the filter1–3, but this migration was not found to be chemotactic3. It seemed to us that our and other people's failure to demonstrate lymphocyte chemotaxis might be because we were using the wrong population of cells. The lymphocytes which can be shown most clearly to migrate into inflammatory lesions in vivo are blast-transformed cells 4–6, and we therefore examined the migration in Boyden chambers of lymphoblasts from two sources; firstly cloned human lymphoblast cell lines maintained in continuous culture7; and secondly blast cells from the lymph nodes of CBA mice, either without deliberate sensitisation with antigen, or following exposure to the contact sensitising agent, oxazolone. Both human and mouse lymphoblasts were shown to migrate into filters towards chemoattractants. The nature of this migration is discussed below. More... »
PAGES646-648
http://scigraph.springernature.com/pub.10.1038/256646a0
DOIhttp://dx.doi.org/10.1038/256646a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1028059217
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/1167269
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Caseins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Movement",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemotaxis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colchicine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Depression, Chemical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dose-Response Relationship, Drug",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred CBA",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oxazolone",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Bacteriology and Immunology, University of Glasgow, Western Infirmary, G11 6NT, Glasgow, UK",
"id": "http://www.grid.ac/institutes/grid.8756.c",
"name": [
"Department of Bacteriology and Immunology, University of Glasgow, Western Infirmary, G11 6NT, Glasgow, UK"
],
"type": "Organization"
},
"familyName": "RUSSELL",
"givenName": "R. J.",
"id": "sg:person.070630224.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.070630224.68"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Bacteriology and Immunology, University of Glasgow, Western Infirmary, G11 6NT, Glasgow, UK",
"id": "http://www.grid.ac/institutes/grid.8756.c",
"name": [
"Department of Bacteriology and Immunology, University of Glasgow, Western Infirmary, G11 6NT, Glasgow, UK"
],
"type": "Organization"
},
"familyName": "WILKINSON",
"givenName": "P. C.",
"id": "sg:person.074471324.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074471324.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Bacteriology and Immunology, University of Glasgow, Western Infirmary, G11 6NT, Glasgow, UK",
"id": "http://www.grid.ac/institutes/grid.8756.c",
"name": [
"Department of Bacteriology and Immunology, University of Glasgow, Western Infirmary, G11 6NT, Glasgow, UK"
],
"type": "Organization"
},
"familyName": "SLESS",
"givenName": "F.",
"id": "sg:person.0100332424.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100332424.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Bacteriology and Immunology, University of Glasgow, Western Infirmary, G11 6NT, Glasgow, UK",
"id": "http://www.grid.ac/institutes/grid.8756.c",
"name": [
"Department of Bacteriology and Immunology, University of Glasgow, Western Infirmary, G11 6NT, Glasgow, UK"
],
"type": "Organization"
},
"familyName": "PARROTT",
"givenName": "DELPHINE M. V.",
"id": "sg:person.016552552464.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016552552464.05"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/newbio232153a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015561353",
"https://doi.org/10.1038/newbio232153a0"
],
"type": "CreativeWork"
}
],
"datePublished": "1975-08",
"datePublishedReg": "1975-08-01",
"description": "LYMPHOCYTES are motile cells whose movement in vivo seems to be directed, yet investigators over many years have repeatedly failed to show chemotaxis of lymphocytes in vitro. There have been some recent reports that lymphocytes migrate into micropore filters towards substances placed below the filter1\u20133, but this migration was not found to be chemotactic3. It seemed to us that our and other people's failure to demonstrate lymphocyte chemotaxis might be because we were using the wrong population of cells. The lymphocytes which can be shown most clearly to migrate into inflammatory lesions in vivo are blast-transformed cells 4\u20136, and we therefore examined the migration in Boyden chambers of lymphoblasts from two sources; firstly cloned human lymphoblast cell lines maintained in continuous culture7; and secondly blast cells from the lymph nodes of CBA mice, either without deliberate sensitisation with antigen, or following exposure to the contact sensitising agent, oxazolone. Both human and mouse lymphoblasts were shown to migrate into filters towards chemoattractants. The nature of this migration is discussed below.",
"genre": "article",
"id": "sg:pub.10.1038/256646a0",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "5519",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "256"
}
],
"keywords": [
"chemotaxis of lymphocytes",
"lymph nodes",
"inflammatory lesions",
"CBA mice",
"lymphocyte chemotaxis",
"Boyden chamber",
"lymphocytes",
"human lymphoblast cell lines",
"mouse lymphoblasts",
"lymphoblast cell lines",
"cells 4",
"micropore filters",
"lymphoblasts",
"cell lines",
"recent reports",
"chemotaxis",
"vivo",
"wrong population",
"cells",
"failure",
"lesions",
"antigen",
"mice",
"sensitisation",
"chemoattractant",
"exposure",
"migration",
"report",
"oxazolone",
"investigators",
"years",
"population",
"agents",
"substances",
"motile cells",
"lines",
"contact",
"nodes",
"movement",
"people's failure",
"chamber",
"source",
"nature",
"filter"
],
"name": "Chemotaxis of lymphoblasts",
"pagination": "646-648",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1028059217"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/256646a0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"1167269"
]
}
],
"sameAs": [
"https://doi.org/10.1038/256646a0",
"https://app.dimensions.ai/details/publication/pub.1028059217"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T21:58",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_152.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/256646a0"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/256646a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/256646a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/256646a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/256646a0'
This table displays all metadata directly associated to this object as RDF triples.
182 TRIPLES
21 PREDICATES
84 URIs
75 LITERALS
20 BLANK NODES