Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-07

AUTHORS

PETER C. DOHERTY, ROLF M. ZINKERNAGEL

ABSTRACT

THE major histocompatibility (H) antigens of higher animals show extreme genetic polymorphism equalled, in higher vertebrates, only by that associated with the immunoglobulins1. Maintenance of such a high rate of variability implies evolutionary advantage for heterozygotes in the HL-A system for man, or at the H-2 gene complex in mice2,3. We propose a possible selective mechanism, based on the realisation that immunological surveillance function (defined here as recognition and elimination of modified host cells by sensitised thymus-derived lymphocytes (T-cells) may be considerably enhanced in mice heterozygous at the H-2 gene complex. More... »

PAGES

50-52

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/256050a0

DOI

http://dx.doi.org/10.1038/256050a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023608866

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1079575


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