Study of cell development using derepressed mutations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-06

AUTHORS

IAN W. DAWES

ABSTRACT

CURRENTLY there is considerable interest in determining how genes are expressed in a highly ordered sequence during morphogenesis. The main genetic approach to this problem has been to study mutants blocked in development. Such mutants are, however, highly pleiotropic; no biochemical or morphological event normally occurring after a point of mutational block is expressed1. This, coupled with inadequate knowledge of biochemical events specific to development2, and the absence of detectable cross feeding between defective mutants3, makes it difficult to determine the precise lesion in any mutant and its place in control of the sequence. Another method, selecting mutations affecting known biochemical functions can be more rewarding but is also hampered by ignorance of biochemical events relevant to development2,4. More... »

PAGES

707

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/255707a0

DOI

http://dx.doi.org/10.1038/255707a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042212825

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1094303


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