Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1975-03

AUTHORS

ROBERT V. BLANDEN, PETER C. DOHERTY, MALCOLM B. C. DUNLOP, IAN D. GARDNER, ROLF M. ZINKERNAGEL, CHELLA S. DAVID

ABSTRACT

EVIDENCE is mounting that in mice, certain specific immunological effector functions of thymus-derived (T) lymphocytes are efficient only when donors of T cells and the cells with which they interact have at least a part of the H-2 gene complex in common1–8. Examples include T helper function in vivo and in vitro1–3, cytotoxicity mediated by T cells against virus-infected4–6 or TNP-modified7 target cells in vitro, immunopathology mediated by T cells4, or protection against bacterial8 and viral infection6in vivo. This requirement for H-2 compatibility has been studied in detail by measuring the cytotoxicity of T cells from donors immunised with either lymphocytic choriomeningitis (LCM) or ectromelia virus using target cells infected with the homologus virus. More... »

PAGES

269-270

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/254269a0

DOI

http://dx.doi.org/10.1038/254269a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041295628

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1078719


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193 grid-institutes:grid.1001.0 schema:alternateName Department of Microbiology, John Curtin School of Medical Research, Australian National University, 2601, Canberra, ACT, Australia
194 schema:name Department of Microbiology, John Curtin School of Medical Research, Australian National University, 2601, Canberra, ACT, Australia
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196 grid-institutes:grid.214458.e schema:alternateName Department of Human Genetics, The University of Michigan Medical School, Ann Arbor, Michigan
197 schema:name Department of Human Genetics, The University of Michigan Medical School, Ann Arbor, Michigan
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