Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-02

AUTHORS

Ramareddy V. Guntaka, Brian W. J. Mahy, J. Michael Bishop, Harold E. Varmus

ABSTRACT

The DNA of avian sarcoma virus assumes a closed circular configuration before integration into the host cell chromosomal DNA. Ethidium bromide reduces the formation of superhelical viral DNA and concurrently blocks integration of the viral genome. Inhibition of integration of viral DNA results in the inhibition of virus replication.

PAGES

507

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/253507a0

DOI

http://dx.doi.org/10.1038/253507a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040295853

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/163973


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