Possible role of prostaglandin F2α in mediating effect of prolactin on RNA synthesis in mammary gland explants of mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-02

AUTHORS

JAMES A. RILLEMA

ABSTRACT

CYCLIC nucleotides seem to be intimately involved in the initiation of lactation and the consequent production of milk substances in the mammary gland1–5. The ratio of cyclic GMP to cyclic AMP increased several-fold in mammary glands taken from rats immediately after parturition and during lactation1,2. Further, dibutyryl cyclic AMP attenuated or abolished several hormone effects on enzyme activities and other metabolic events in explants from mid-pregnant rats3. It seems that the regulation of the metabolism of the mammary glands of mice may be specifically related to the mechanism whereby prolactin affects this tissue4,5: cyclic GMP mimicked the early action of prolactin on RNA synthesis in mammary gland explants, whereas dibutyryl cyclic AMP and agents which inhibit phosphodiesterase abolished this effect. These observations suggest that the early effect of prolactin on RNA synthesis is mediated by an elevated level of cyclic GMP and a reduced or maintained level of cyclic AMP. More... »

PAGES

466

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/253466a0

DOI

http://dx.doi.org/10.1038/253466a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036492066

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1110798


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Culture Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indomethacin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Glands, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prolactin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostaglandins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "RILLEMA", 
        "givenName": "JAMES A.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1974.tb03694.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004443355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/240411a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005781437", 
          "https://doi.org/10.1038/240411a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-6980(74)80116-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010427580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(74)80201-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020845647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/229568a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027385673", 
          "https://doi.org/10.1038/229568a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(74)80363-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034868003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-92-6-1673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064275576"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1975-02", 
    "datePublishedReg": "1975-02-01", 
    "description": "CYCLIC nucleotides seem to be intimately involved in the initiation of lactation and the consequent production of milk substances in the mammary gland1\u20135. The ratio of cyclic GMP to cyclic AMP increased several-fold in mammary glands taken from rats immediately after parturition and during lactation1,2. Further, dibutyryl cyclic AMP attenuated or abolished several hormone effects on enzyme activities and other metabolic events in explants from mid-pregnant rats3. It seems that the regulation of the metabolism of the mammary glands of mice may be specifically related to the mechanism whereby prolactin affects this tissue4,5: cyclic GMP mimicked the early action of prolactin on RNA synthesis in mammary gland explants, whereas dibutyryl cyclic AMP and agents which inhibit phosphodiesterase abolished this effect. These observations suggest that the early effect of prolactin on RNA synthesis is mediated by an elevated level of cyclic GMP and a reduced or maintained level of cyclic AMP.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/253466a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5491", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "253"
      }
    ], 
    "name": "Possible role of prostaglandin F2\u03b1 in mediating effect of prolactin on RNA synthesis in mammary gland explants of mice", 
    "pagination": "466", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "add57a6aa2073abea8eef43b03a26096d46150b6ff9ec15baaba9a73b4fdd37c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1110798"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/253466a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036492066"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/253466a0", 
      "https://app.dimensions.ai/details/publication/pub.1036492066"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/253466a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/253466a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/253466a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/253466a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/253466a0'


 

This table displays all metadata directly associated to this object as RDF triples.

131 TRIPLES      21 PREDICATES      47 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/253466a0 schema:about N03b5f44399a14542934b92c9b82440e9
2 N2084709f1f304a73b1510023b524c857
3 N2d1b543267c049b69b29aae723bb8e23
4 N3c6cdc2aff5d4a4bb90ce5e10213e374
5 N4e075dc2a26540d29d3385fa50cc7e3c
6 N52e8b23e1f6a49d0bc3f78a8d9d3597b
7 N7aff9b8617b54861abe9ccab1ae7858d
8 Nc21f9f8a38e04e32861a1394ecc2675b
9 Nd569e6a4f45c4d53b8129b9f480d182b
10 Necb6486f5e1b488a82c74f9e15212201
11 Nfee0fc73b70742fea14b8fa63411a774
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N9b9b5376bd824853891f0b904a1b3809
15 schema:citation sg:pub.10.1038/229568a0
16 sg:pub.10.1038/240411a0
17 https://doi.org/10.1016/0014-5793(74)80363-7
18 https://doi.org/10.1016/s0006-291x(74)80201-9
19 https://doi.org/10.1016/s0090-6980(74)80116-4
20 https://doi.org/10.1111/j.1432-1033.1974.tb03694.x
21 https://doi.org/10.1210/endo-92-6-1673
22 schema:datePublished 1975-02
23 schema:datePublishedReg 1975-02-01
24 schema:description CYCLIC nucleotides seem to be intimately involved in the initiation of lactation and the consequent production of milk substances in the mammary gland1–5. The ratio of cyclic GMP to cyclic AMP increased several-fold in mammary glands taken from rats immediately after parturition and during lactation1,2. Further, dibutyryl cyclic AMP attenuated or abolished several hormone effects on enzyme activities and other metabolic events in explants from mid-pregnant rats3. It seems that the regulation of the metabolism of the mammary glands of mice may be specifically related to the mechanism whereby prolactin affects this tissue4,5: cyclic GMP mimicked the early action of prolactin on RNA synthesis in mammary gland explants, whereas dibutyryl cyclic AMP and agents which inhibit phosphodiesterase abolished this effect. These observations suggest that the early effect of prolactin on RNA synthesis is mediated by an elevated level of cyclic GMP and a reduced or maintained level of cyclic AMP.
25 schema:genre research_article
26 schema:inLanguage en
27 schema:isAccessibleForFree false
28 schema:isPartOf N3b2bb8bb36cd48d4b183d7a54da7b8e0
29 Nabfd85ebf40343568e1e7b617b6501a0
30 sg:journal.1018957
31 schema:name Possible role of prostaglandin F2α in mediating effect of prolactin on RNA synthesis in mammary gland explants of mice
32 schema:pagination 466
33 schema:productId N3fcbaf6500ea478dbeffae366db2cf3d
34 N9d77dc2b489a430b8b94af3aff977b7c
35 Na5103697846148ed8b0f35ae88b11504
36 Nbf31799991214bae9904332051f0f037
37 Nd823bc401112470e9d08f437d8eb3538
38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036492066
39 https://doi.org/10.1038/253466a0
40 schema:sdDatePublished 2019-04-10T16:29
41 schema:sdLicense https://scigraph.springernature.com/explorer/license/
42 schema:sdPublisher N65b28b0860a342c882785ddef9afa793
43 schema:url https://www.nature.com/articles/253466a0
44 sgo:license sg:explorer/license/
45 sgo:sdDataset articles
46 rdf:type schema:ScholarlyArticle
47 N03b5f44399a14542934b92c9b82440e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
48 schema:name Prostaglandins
49 rdf:type schema:DefinedTerm
50 N2084709f1f304a73b1510023b524c857 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
51 schema:name Animals
52 rdf:type schema:DefinedTerm
53 N2d1b543267c049b69b29aae723bb8e23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
54 schema:name Culture Techniques
55 rdf:type schema:DefinedTerm
56 N3b2bb8bb36cd48d4b183d7a54da7b8e0 schema:volumeNumber 253
57 rdf:type schema:PublicationVolume
58 N3c6cdc2aff5d4a4bb90ce5e10213e374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Mice
60 rdf:type schema:DefinedTerm
61 N3fcbaf6500ea478dbeffae366db2cf3d schema:name doi
62 schema:value 10.1038/253466a0
63 rdf:type schema:PropertyValue
64 N4e075dc2a26540d29d3385fa50cc7e3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Kinetics
66 rdf:type schema:DefinedTerm
67 N52e8b23e1f6a49d0bc3f78a8d9d3597b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Female
69 rdf:type schema:DefinedTerm
70 N65b28b0860a342c882785ddef9afa793 schema:name Springer Nature - SN SciGraph project
71 rdf:type schema:Organization
72 N7aff9b8617b54861abe9ccab1ae7858d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Mammary Glands, Animal
74 rdf:type schema:DefinedTerm
75 N9b9b5376bd824853891f0b904a1b3809 rdf:first Ne7b04e5f75bb494691a0ff00b993c539
76 rdf:rest rdf:nil
77 N9d77dc2b489a430b8b94af3aff977b7c schema:name dimensions_id
78 schema:value pub.1036492066
79 rdf:type schema:PropertyValue
80 Na5103697846148ed8b0f35ae88b11504 schema:name pubmed_id
81 schema:value 1110798
82 rdf:type schema:PropertyValue
83 Nabfd85ebf40343568e1e7b617b6501a0 schema:issueNumber 5491
84 rdf:type schema:PublicationIssue
85 Nbf31799991214bae9904332051f0f037 schema:name readcube_id
86 schema:value add57a6aa2073abea8eef43b03a26096d46150b6ff9ec15baaba9a73b4fdd37c
87 rdf:type schema:PropertyValue
88 Nc21f9f8a38e04e32861a1394ecc2675b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name RNA
90 rdf:type schema:DefinedTerm
91 Nd569e6a4f45c4d53b8129b9f480d182b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Drug Interactions
93 rdf:type schema:DefinedTerm
94 Nd823bc401112470e9d08f437d8eb3538 schema:name nlm_unique_id
95 schema:value 0410462
96 rdf:type schema:PropertyValue
97 Ne7b04e5f75bb494691a0ff00b993c539 schema:familyName RILLEMA
98 schema:givenName JAMES A.
99 rdf:type schema:Person
100 Necb6486f5e1b488a82c74f9e15212201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Indomethacin
102 rdf:type schema:DefinedTerm
103 Nfee0fc73b70742fea14b8fa63411a774 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Prolactin
105 rdf:type schema:DefinedTerm
106 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
107 schema:name Medical and Health Sciences
108 rdf:type schema:DefinedTerm
109 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
110 schema:name Clinical Sciences
111 rdf:type schema:DefinedTerm
112 sg:journal.1018957 schema:issn 0090-0028
113 1476-4687
114 schema:name Nature
115 rdf:type schema:Periodical
116 sg:pub.10.1038/229568a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027385673
117 https://doi.org/10.1038/229568a0
118 rdf:type schema:CreativeWork
119 sg:pub.10.1038/240411a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005781437
120 https://doi.org/10.1038/240411a0
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1016/0014-5793(74)80363-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034868003
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1016/s0006-291x(74)80201-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020845647
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1016/s0090-6980(74)80116-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010427580
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1111/j.1432-1033.1974.tb03694.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004443355
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1210/endo-92-6-1673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064275576
131 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...