Ultrastructural analysis of toxin binding and entry into mammalian cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-10

AUTHORS

GH L. NICOLSON

ABSTRACT

VERY low concentrations of phytotoxins can kill mammalian cells, and some of them, such as ricin and abrin, isolated from Ricinus communis and Abrus precatorius, have been reported to suppress protein synthesis in cells1–3 and cell-free systems4,5. Ricin inhibits peptide chain elongation by catalytically inactivating the 60S subunits of ribosomes5–7. It is a galactosebinding glycoprotein of molecular weight 60,000, containing two nonidentical subunits linked by disulphide bridges8–11 and seems to be identical to the lectin R. communis agglutinin II (RCAII) isolated by affinity chromatography8–12. Ricin, or RCAII, has been used to suppress the growth of ascites tumour cells in vivo13, and as a cell surface probe for oligosaccharide receptors14–17 containing terminal D-galactose or N-acetyl-D-galactosamine-like saccharides11,14,18,19. I have found that RCAII enters mammalian cells by endocytosis (similar to the findings of Oliver et al.20) and is then released into the cytoplasm, where it apparently acts directly on protein synthesis. More... »

PAGES

628

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/251628a0

DOI

http://dx.doi.org/10.1038/251628a0

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4417936


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53 schema:description VERY low concentrations of phytotoxins can kill mammalian cells, and some of them, such as ricin and abrin, isolated from Ricinus communis and Abrus precatorius, have been reported to suppress protein synthesis in cells1–3 and cell-free systems4,5. Ricin inhibits peptide chain elongation by catalytically inactivating the 60S subunits of ribosomes5–7. It is a galactosebinding glycoprotein of molecular weight 60,000, containing two nonidentical subunits linked by disulphide bridges8–11 and seems to be identical to the lectin R. communis agglutinin II (RCAII) isolated by affinity chromatography8–12. Ricin, or RCAII, has been used to suppress the growth of ascites tumour cells in vivo13, and as a cell surface probe for oligosaccharide receptors14–17 containing terminal D-galactose or N-acetyl-D-galactosamine-like saccharides11,14,18,19. I have found that RCAII enters mammalian cells by endocytosis (similar to the findings of Oliver et al.20) and is then released into the cytoplasm, where it apparently acts directly on protein synthesis.
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